Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7

The question of the effect of anti-TNF-alpha in skin carcinogenesis is especially relevant in view of the increased use of these drugs for the treatment of autoinflammatory immune diseases. Since ultraviolet radiation and human papillomavirus are involved in skin carcinogenesis, we wished to investi...

Descripción completa

Detalles Bibliográficos
Autores principales: Aubin, François, Gheit, Tarik, Prétet, Jean Luc, Tommasino, Massimo, Mougin, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596906/
https://www.ncbi.nlm.nih.gov/pubmed/23533798
http://dx.doi.org/10.1155/2013/907189
_version_ 1782262571048370176
author Aubin, François
Gheit, Tarik
Prétet, Jean Luc
Tommasino, Massimo
Mougin, Christiane
author_facet Aubin, François
Gheit, Tarik
Prétet, Jean Luc
Tommasino, Massimo
Mougin, Christiane
author_sort Aubin, François
collection PubMed
description The question of the effect of anti-TNF-alpha in skin carcinogenesis is especially relevant in view of the increased use of these drugs for the treatment of autoinflammatory immune diseases. Since ultraviolet radiation and human papillomavirus are involved in skin carcinogenesis, we wished to investigate the effect of TNF-alpha antagonists on the UVB-induced apoptosis of keratinocytes infected by HPV38. Our results indicate that anti-TNF agent, infliximab, does not contribute to the survival of HPV38-transduced keratinocytes with UVB-induced DNA damages.
format Online
Article
Text
id pubmed-3596906
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35969062013-03-26 Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7 Aubin, François Gheit, Tarik Prétet, Jean Luc Tommasino, Massimo Mougin, Christiane ISRN Dermatol Research Article The question of the effect of anti-TNF-alpha in skin carcinogenesis is especially relevant in view of the increased use of these drugs for the treatment of autoinflammatory immune diseases. Since ultraviolet radiation and human papillomavirus are involved in skin carcinogenesis, we wished to investigate the effect of TNF-alpha antagonists on the UVB-induced apoptosis of keratinocytes infected by HPV38. Our results indicate that anti-TNF agent, infliximab, does not contribute to the survival of HPV38-transduced keratinocytes with UVB-induced DNA damages. Hindawi Publishing Corporation 2013-02-25 /pmc/articles/PMC3596906/ /pubmed/23533798 http://dx.doi.org/10.1155/2013/907189 Text en Copyright © 2013 François Aubin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aubin, François
Gheit, Tarik
Prétet, Jean Luc
Tommasino, Massimo
Mougin, Christiane
Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7
title Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7
title_full Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7
title_fullStr Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7
title_full_unstemmed Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7
title_short Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7
title_sort effect of infliximab on the uvb-induced apoptosis of keratinocytes infected by hpv38 e6/e7
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596906/
https://www.ncbi.nlm.nih.gov/pubmed/23533798
http://dx.doi.org/10.1155/2013/907189
work_keys_str_mv AT aubinfrancois effectofinfliximabontheuvbinducedapoptosisofkeratinocytesinfectedbyhpv38e6e7
AT gheittarik effectofinfliximabontheuvbinducedapoptosisofkeratinocytesinfectedbyhpv38e6e7
AT pretetjeanluc effectofinfliximabontheuvbinducedapoptosisofkeratinocytesinfectedbyhpv38e6e7
AT tommasinomassimo effectofinfliximabontheuvbinducedapoptosisofkeratinocytesinfectedbyhpv38e6e7
AT mouginchristiane effectofinfliximabontheuvbinducedapoptosisofkeratinocytesinfectedbyhpv38e6e7

Ejemplares similares