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Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain
PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19–64 years) underwent diffusional kurtosis imaging...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596978/ https://www.ncbi.nlm.nih.gov/pubmed/23055442 http://dx.doi.org/10.1002/jmri.23857 |
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author | Lätt, Jimmy Nilsson, Markus Wirestam, Ronnie Ståhlberg, Freddy Karlsson, Nils Johansson, Mikael Sundgren, Pia C van Westen, Danielle |
author_facet | Lätt, Jimmy Nilsson, Markus Wirestam, Ronnie Ståhlberg, Freddy Karlsson, Nils Johansson, Mikael Sundgren, Pia C van Westen, Danielle |
author_sort | Lätt, Jimmy |
collection | PubMed |
description | PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19–64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2)/ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2013;37:610–618. © 2012 Wiley Periodicals, Inc. |
format | Online Article Text |
id | pubmed-3596978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Wiley Subscription Services, Inc., A Wiley Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-35969782013-03-19 Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain Lätt, Jimmy Nilsson, Markus Wirestam, Ronnie Ståhlberg, Freddy Karlsson, Nils Johansson, Mikael Sundgren, Pia C van Westen, Danielle J Magn Reson Imaging Original Research—Neuroimaging PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19–64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2)/ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2013;37:610–618. © 2012 Wiley Periodicals, Inc. Wiley Subscription Services, Inc., A Wiley Company 2013-03 2012-10-10 /pmc/articles/PMC3596978/ /pubmed/23055442 http://dx.doi.org/10.1002/jmri.23857 Text en Copyright © 2012 Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Original Research—Neuroimaging Lätt, Jimmy Nilsson, Markus Wirestam, Ronnie Ståhlberg, Freddy Karlsson, Nils Johansson, Mikael Sundgren, Pia C van Westen, Danielle Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain |
title | Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain |
title_full | Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain |
title_fullStr | Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain |
title_full_unstemmed | Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain |
title_short | Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain |
title_sort | regional values of diffusional kurtosis estimates in the healthy brain |
topic | Original Research—Neuroimaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596978/ https://www.ncbi.nlm.nih.gov/pubmed/23055442 http://dx.doi.org/10.1002/jmri.23857 |
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