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Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain

PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19–64 years) underwent diffusional kurtosis imaging...

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Autores principales: Lätt, Jimmy, Nilsson, Markus, Wirestam, Ronnie, Ståhlberg, Freddy, Karlsson, Nils, Johansson, Mikael, Sundgren, Pia C, van Westen, Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596978/
https://www.ncbi.nlm.nih.gov/pubmed/23055442
http://dx.doi.org/10.1002/jmri.23857
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author Lätt, Jimmy
Nilsson, Markus
Wirestam, Ronnie
Ståhlberg, Freddy
Karlsson, Nils
Johansson, Mikael
Sundgren, Pia C
van Westen, Danielle
author_facet Lätt, Jimmy
Nilsson, Markus
Wirestam, Ronnie
Ståhlberg, Freddy
Karlsson, Nils
Johansson, Mikael
Sundgren, Pia C
van Westen, Danielle
author_sort Lätt, Jimmy
collection PubMed
description PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19–64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2)/ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2013;37:610–618. © 2012 Wiley Periodicals, Inc.
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spelling pubmed-35969782013-03-19 Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain Lätt, Jimmy Nilsson, Markus Wirestam, Ronnie Ståhlberg, Freddy Karlsson, Nils Johansson, Mikael Sundgren, Pia C van Westen, Danielle J Magn Reson Imaging Original Research—Neuroimaging PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19–64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2)/ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2013;37:610–618. © 2012 Wiley Periodicals, Inc. Wiley Subscription Services, Inc., A Wiley Company 2013-03 2012-10-10 /pmc/articles/PMC3596978/ /pubmed/23055442 http://dx.doi.org/10.1002/jmri.23857 Text en Copyright © 2012 Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Research—Neuroimaging
Lätt, Jimmy
Nilsson, Markus
Wirestam, Ronnie
Ståhlberg, Freddy
Karlsson, Nils
Johansson, Mikael
Sundgren, Pia C
van Westen, Danielle
Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain
title Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain
title_full Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain
title_fullStr Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain
title_full_unstemmed Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain
title_short Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain
title_sort regional values of diffusional kurtosis estimates in the healthy brain
topic Original Research—Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596978/
https://www.ncbi.nlm.nih.gov/pubmed/23055442
http://dx.doi.org/10.1002/jmri.23857
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