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Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides
Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596983/ https://www.ncbi.nlm.nih.gov/pubmed/23492626 http://dx.doi.org/10.1038/srep01456 |
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author | Zhu, Fang Gujar, Hemant Gordon, Jennifer R. Haynes, Kenneth F. Potter, Michael F. Palli, Subba R. |
author_facet | Zhu, Fang Gujar, Hemant Gordon, Jennifer R. Haynes, Kenneth F. Potter, Michael F. Palli, Subba R. |
author_sort | Zhu, Fang |
collection | PubMed |
description | Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies revealed that most of the resistance-associated genes functioning in diverse mechanisms are expressed in the epidermal layer of the integument, which could prevent or slow down the toxin from reaching the target sites on nerve cells, where an additional layer of resistance (kdr) is possible. This strategy evolved in bed bugs is based on their unique morphological, physiological and behavioral characteristics and has not been reported in any other insect species. RNA interference-aided knockdown of resistance associated genes showed the relative contribution of each mechanism towards overall resistance development. Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods. |
format | Online Article Text |
id | pubmed-3596983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-35969832013-03-14 Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides Zhu, Fang Gujar, Hemant Gordon, Jennifer R. Haynes, Kenneth F. Potter, Michael F. Palli, Subba R. Sci Rep Article Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies revealed that most of the resistance-associated genes functioning in diverse mechanisms are expressed in the epidermal layer of the integument, which could prevent or slow down the toxin from reaching the target sites on nerve cells, where an additional layer of resistance (kdr) is possible. This strategy evolved in bed bugs is based on their unique morphological, physiological and behavioral characteristics and has not been reported in any other insect species. RNA interference-aided knockdown of resistance associated genes showed the relative contribution of each mechanism towards overall resistance development. Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods. Nature Publishing Group 2013-03-14 /pmc/articles/PMC3596983/ /pubmed/23492626 http://dx.doi.org/10.1038/srep01456 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Zhu, Fang Gujar, Hemant Gordon, Jennifer R. Haynes, Kenneth F. Potter, Michael F. Palli, Subba R. Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides |
title | Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides |
title_full | Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides |
title_fullStr | Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides |
title_full_unstemmed | Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides |
title_short | Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides |
title_sort | bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596983/ https://www.ncbi.nlm.nih.gov/pubmed/23492626 http://dx.doi.org/10.1038/srep01456 |
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