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Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice

Both CLN1 and CLN5 deficiencies lead to severe neurodegenerative diseases of childhood, known as neuronal ceroid lipofuscinoses (NCLs). The broadly similar phenotypes of NCL mouse models, and the potential for interactions between NCL proteins, raise the possibility of shared or convergent disease m...

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Detalles Bibliográficos
Autores principales:	Blom, Tea, Schmiedt, Mia-Lisa, Wong, Andrew M., Kyttälä, Aija, Soronen, Jarkko, Jauhiainen, Matti, Tyynelä, Jaana, Cooper, Jonathan D., Jalanko, Anu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597017/ https://www.ncbi.nlm.nih.gov/pubmed/23065637 http://dx.doi.org/10.1242/dmm.010140

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