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Mice deficient in H(+)-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear
Mutations in the ATP6V0A4 gene lead to autosomal recessive distal renal tubular acidosis in patients, who often show sensorineural hearing impairment. A first Atp6v0a4 knockout mouse model that recapitulates the loss of H(+)-ATPase function seen in humans has been generated and recently reported (No...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Limited
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597025/ https://www.ncbi.nlm.nih.gov/pubmed/23065636 http://dx.doi.org/10.1242/dmm.010645 |