Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome

Mutations in the WAS gene cause Wiskott-Aldrich syndrome (WAS), which is characterized by eczema, immunodeficiency and microthrombocytopenia. Although the role of WASP in lymphocytes and myeloid cells is well characterized, its role on megakaryocyte (MK) development is poorly understood. In order to...

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Detalles Bibliográficos
Autores principales: Toscano, Miguel G., Anderson, Per, Muñoz, Pilar, Lucena, Gema, Cobo, Marién, Benabdellah, Karim, Gregory, Philip D., Holmes, Michael C., Martin, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Resource Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597037/
https://www.ncbi.nlm.nih.gov/pubmed/23324327
http://dx.doi.org/10.1242/dmm.010652

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