Cargando…

Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation

The development of synthetic methodologies for cyclic peptides is driven by the discovery of cyclic peptide drug scaffolds such as the plant-derived cyclotides, sunflower trypsin inhibitor 1 (SFTI-1) and the development of cyclized conotoxins. Currently, the native chemical ligation reaction between...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gunasekera, Sunithi, Aboye, Teshome L., Madian, Walid A., El-Seedi, Hesham R., Göransson, Ulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597280/ https://www.ncbi.nlm.nih.gov/pubmed/23504256 http://dx.doi.org/10.1007/s10989-012-9331-y

Ejemplares similares

Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
por: Muhammad, Taj, et al.
Publicado: (2023)

Native and Engineered Cyclic Disulfide-Rich Peptides as Drug Leads
por: Tyler, Tristan J., et al.
Publicado: (2023)

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
por: Gunasekera, Sunithi, et al.
Publicado: (2020)

Diastereospecific arylation and cascade deconstructive amidation/thioesterification of readily available lactam-fused bromolactones
por: Do, Minh, et al.
Publicado: (2023)

Exploring the Limits of Cyanobactin Macrocyclase PatGmac: Cyclization of PawS-Derived Peptide Sunflower Trypsin Inhibitor-1 and Cyclotide Kalata B1
por: Muhammad, Taj, et al.
Publicado: (2023)

Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti
por: Steffen, Karin, et al.
Publicado: (2021)

Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides
por: Ollivier, Nathalie, et al.
Publicado: (2018)

Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides
por: Hering, Anke, et al.
Publicado: (2022)

Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins
por: Hellinger, Roland, et al.
Publicado: (2017)

The Membrane-Active Phytopeptide Cycloviolacin O2 Simultaneously Targets HIV-1-infected Cells and Infectious Viral Particles to Potentiate the Efficacy of Antiretroviral Drugs
por: Gerlach, Samantha L., et al.
Publicado: (2019)

Tunable Aryl Imidazolium Recyclable Ionic Liquid with Dual Brønsted–Lewis Acid as Green Catalyst for Friedel–Crafts Acylation and Thioesterification
por: Lin, Yi-Jyun, et al.
Publicado: (2020)

Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens
por: Rajendran, Sanjeevan, et al.
Publicado: (2022)

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes
por: Yan, Wenjing, et al.
Publicado: (2023)

A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens
por: White, John Kerr, et al.
Publicado: (2022)

New Deoxyribozymes for the Native Ligation of RNA
por: Scheitl, Carolin P. M., et al.
Publicado: (2020)

Tyrosine phosphorylation profiling via in situ proximity ligation assay
por: Elfineh, Lioudmila, et al.
Publicado: (2014)

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens
por: Fernandes-Cerqueira, Cátia, et al.
Publicado: (2015)

Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools
por: Chan, Lai Yue, et al.
Publicado: (2023)

Antimicrobial activity of filamentous fungi isolated from highly antibiotic-contaminated river sediment
por: Svahn, K. Stefan, et al.
Publicado: (2012)

A new method of N to C sequential ligation using thioacid capture ligation and native chemical ligation
por: Hou, Wen, et al.
Publicado: (2018)

Multiple Disulfide-Bonded States of Native Proteins: Estimate of Number Using Probabilities of Disulfide Bond Formation
por: Hogg, Philip J.
Publicado: (2020)

(E)-Ethyl-2-cyano-2-(((2,4,6-trichlorobenzoyl)oxy)imino)acetate: A Modified Yamaguchi Reagent for Enantioselective Esterification, Thioesterification, Amidation, and Peptide Synthesis
por: Chandra, Jyoti, et al.
Publicado: (2018)

Sequencing by Cyclic Ligation and Cleavage (CycLiC) directly on a microarray captured template
por: Mir, Kalim U., et al.
Publicado: (2009)

Converting disulfide bridges in native peptides to stable methylene thioacetals
por: Kourra, C. M. B. K., et al.
Publicado: (2016)

DNA origami deposition on native and passivated molybdenum disulfide substrates
por: Zhang, Xiaoning, et al.
Publicado: (2014)

Good Practices in Sponge Natural Product Studies: Revising Vouchers with Isomalabaricane Triterpenes
por: Cárdenas, Paco, et al.
Publicado: (2022)

Small Cyclic Peptide for Pyrophosphate Dependent Ligation in Prebiotic Environments
por: Piast, Radosław W., et al.
Publicado: (2020)

Native Chemical Ligation: A Boon to Peptide Chemistry
por: Thapa, Parashar, et al.
Publicado: (2014)

Enabling Peptide Ligation at Aromatic Junction Mimics via Native Chemical Ligation and Palladium-Mediated S-Arylation
por: Lin, Xiaoxi, et al.
Publicado: (2023)

Oxidation of Disulfides to Thiolsulfinates with Hydrogen Peroxide and a Cyclic Seleninate Ester Catalyst
por: McNeil, Nicole M. R., et al.
Publicado: (2015)

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically
por: Felber, Jan G., et al.
Publicado: (2022)

The Role of the Disulfide Bridge in the Copper (II) Binding by the Cyclic His(4)-Peptide
por: Pieniężna, Aleksandra, et al.
Publicado: (2021)

Cyclic Digestion and Ligation-Mediated PCR Used for Flanking Sequence Walking
por: Yu, Dong, et al.
Publicado: (2020)

Native Chemical Ligation for Cross-Linking of Flower-Like Micelles
por: Najafi, Marzieh, et al.
Publicado: (2018)

A versatile o-aminoanilide linker for native chemical ligation
por: Sánchez-Campillo, Iván, et al.
Publicado: (2022)

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
por: Klaesson, Axel, et al.
Publicado: (2018)

Enabling Cysteine‐Free Native Chemical Ligation at Challenging Junctions with a Ligation Auxiliary Capable of Base Catalysis
por: Fuchs, Olaf, et al.
Publicado: (2021)

Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration
por: Chan, Lai Yue, et al.
Publicado: (2015)

Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I
por: Miura, Shigenori, et al.
Publicado: (2012)

Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond
por: Tao, Huanyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ag7a2qkbuhv3eut9qipl4pfucf