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Is myelin a mitochondrion?
It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597375/ https://www.ncbi.nlm.nih.gov/pubmed/23072751 http://dx.doi.org/10.1038/jcbfm.2012.148 |
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author | Harris, Julia J Attwell, David |
author_facet | Harris, Julia J Attwell, David |
author_sort | Harris, Julia J |
collection | PubMed |
description | It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin membrane to synthesize ATP. In fact, if the respiratory chain were present in the myelin membrane, then the ATP synthase would function in reverse, hydrolyzing rather than synthesizing ATP. This calculation places the hypothesis of an energy-producing role for myelin in considerable doubt. |
format | Online Article Text |
id | pubmed-3597375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-35973752013-03-15 Is myelin a mitochondrion? Harris, Julia J Attwell, David J Cereb Blood Flow Metab Brief Opinion Article It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin membrane to synthesize ATP. In fact, if the respiratory chain were present in the myelin membrane, then the ATP synthase would function in reverse, hydrolyzing rather than synthesizing ATP. This calculation places the hypothesis of an energy-producing role for myelin in considerable doubt. Nature Publishing Group 2013-01 2012-10-17 /pmc/articles/PMC3597375/ /pubmed/23072751 http://dx.doi.org/10.1038/jcbfm.2012.148 Text en Copyright © 2013 International Society for Cerebral Blood Flow & Metabolism, Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Brief Opinion Article Harris, Julia J Attwell, David Is myelin a mitochondrion? |
title | Is myelin a mitochondrion? |
title_full | Is myelin a mitochondrion? |
title_fullStr | Is myelin a mitochondrion? |
title_full_unstemmed | Is myelin a mitochondrion? |
title_short | Is myelin a mitochondrion? |
title_sort | is myelin a mitochondrion? |
topic | Brief Opinion Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597375/ https://www.ncbi.nlm.nih.gov/pubmed/23072751 http://dx.doi.org/10.1038/jcbfm.2012.148 |
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