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Is myelin a mitochondrion?

It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could...

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Detalles Bibliográficos
Autores principales: Harris, Julia J, Attwell, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597375/
https://www.ncbi.nlm.nih.gov/pubmed/23072751
http://dx.doi.org/10.1038/jcbfm.2012.148
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author Harris, Julia J
Attwell, David
author_facet Harris, Julia J
Attwell, David
author_sort Harris, Julia J
collection PubMed
description It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin membrane to synthesize ATP. In fact, if the respiratory chain were present in the myelin membrane, then the ATP synthase would function in reverse, hydrolyzing rather than synthesizing ATP. This calculation places the hypothesis of an energy-producing role for myelin in considerable doubt.
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spelling pubmed-35973752013-03-15 Is myelin a mitochondrion? Harris, Julia J Attwell, David J Cereb Blood Flow Metab Brief Opinion Article It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin membrane to synthesize ATP. In fact, if the respiratory chain were present in the myelin membrane, then the ATP synthase would function in reverse, hydrolyzing rather than synthesizing ATP. This calculation places the hypothesis of an energy-producing role for myelin in considerable doubt. Nature Publishing Group 2013-01 2012-10-17 /pmc/articles/PMC3597375/ /pubmed/23072751 http://dx.doi.org/10.1038/jcbfm.2012.148 Text en Copyright © 2013 International Society for Cerebral Blood Flow & Metabolism, Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Brief Opinion Article
Harris, Julia J
Attwell, David
Is myelin a mitochondrion?
title Is myelin a mitochondrion?
title_full Is myelin a mitochondrion?
title_fullStr Is myelin a mitochondrion?
title_full_unstemmed Is myelin a mitochondrion?
title_short Is myelin a mitochondrion?
title_sort is myelin a mitochondrion?
topic Brief Opinion Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597375/
https://www.ncbi.nlm.nih.gov/pubmed/23072751
http://dx.doi.org/10.1038/jcbfm.2012.148
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