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Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse
Changes in histone acetylation occur during oocyte development and maturation, but the role of specific histone deacetylases in these processes is poorly defined. We report here that mice harboring Hdac1 (−/+)/Hdac2 (−/−) or Hdac2 (−/−) oocytes are infertile or sub-fertile, respectively. Depleting m...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597510/ https://www.ncbi.nlm.nih.gov/pubmed/23516383 http://dx.doi.org/10.1371/journal.pgen.1003377 |