Cargando…

The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression

The importance of anticancer stem cell research for breast cancer lies in the possibility of providing new approaches for an improved understanding of anticancer activity and cancer treatment. In this study, we demonstrated that the preclinical therapeutic efficacy of combining the multikinase inhib...

Descripción completa

Detalles Bibliográficos
Autores principales:	LEE, JAE HO, SHIM, JAE WOONG, CHOI, YOO JIN, HEO, KYU, YANG, KWANGMO
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597559/ https://www.ncbi.nlm.nih.gov/pubmed/23314174 http://dx.doi.org/10.3892/or.2013.2228

Ejemplares similares

Role of HIF1α Regulatory Factors in Stem Cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells
por: Kim, Ji-Hyun, et al.
Publicado: (2017)

Combination Effect of Epigenetic Regulation and Ionizing Radiation in Colorectal Cancer Cells
por: Kim, Joong-Gook, et al.
Publicado: (2014)

Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells
por: Nawara, Hend M., et al.
Publicado: (2020)

Identification of preferential target sites for human DNA methyltransferases
por: Choi, Si Ho, et al.
Publicado: (2011)

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells
por: Moreno Roig, Eloy, et al.
Publicado: (2019)

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia
por: Martín-Aragón Baudel, Miguel A. S., et al.
Publicado: (2017)

miR-519d-3p suppresses tumorigenicity and metastasis by inhibiting Bcl-w and HIF-1α in NSCLC
por: Choi, Jae Yeon, et al.
Publicado: (2021)

Chemotherapy regimen based on sorafenib combined with 5-FU on HIF-1α and VEGF expression and survival in advanced gastric cancer patients
por: Cheng, Ronghui, et al.
Publicado: (2017)

Cryptochromes Suppress HIF1α in Muscles
por: Vaughan, Megan E., et al.
Publicado: (2020)

Sorafenib promotes hepatocellular carcinoma invasion via interleukin-6/HIF-1α/PFKFB3
por: Zhuang, Pengyuan, et al.
Publicado: (2023)

DYRK1A suppression attenuates HIF-1α accumulation and enhances the anti-liver cancer effects of regorafenib and sorafenib under hypoxic conditions
por: Zhang, Chong, et al.
Publicado: (2022)

Downregulation of complement factor H attenuates the stemness of MDA‑MB‑231 breast cancer cells via modulation of the ERK and p38 signaling pathways
por: Park, Soon Yong, et al.
Publicado: (2023)

Suppression of HIF-1α by Valproic Acid Sustains Self-Renewal of Mouse Embryonic Stem Cells under Hypoxia In Vitro
por: Lee, Hyo-Jong, et al.
Publicado: (2012)

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
por: Vukovic, Milica, et al.
Publicado: (2015)

Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation
por: Jang, Yunseon, et al.
Publicado: (2015)

G9a Knockdown Suppresses Cancer Aggressiveness by Facilitating Smad Protein Phosphorylation through Increasing BMP5 Expression in Luminal A Type Breast Cancer
por: Jin, Yunho, et al.
Publicado: (2022)

BICD1 mediates HIF1α nuclear translocation in mesenchymal stem cells during hypoxia adaptation
por: Lee, Hyun Jik, et al.
Publicado: (2018)

Melittin Suppresses HIF-1α/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinoma Cells
por: Shin, Jae-Moon, et al.
Publicado: (2013)

Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells
por: Son, Cheol-Hun, et al.
Publicado: (2016)

A new role for Hif-1α
por: Shin, Mingyu, et al.
Publicado: (2022)

Sorafenib-triggered radiation recall dermatitis with a disseminated exanthematous reaction
por: Oh, Dongryul, et al.
Publicado: (2013)

HIF-2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells
por: Das, Bikul, et al.
Publicado: (2012)

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α
por: Shin, Mi-Kyung, et al.
Publicado: (2012)

Identification of radiation-induced aberrant hypomethylation in colon cancer
por: Bae, Jin-Han, et al.
Publicado: (2015)

USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis
por: Gao, Ruize, et al.
Publicado: (2021)

Extraordinary radiation super-sensitivity accompanying with sorafenib combination therapy: what lies beneath?
por: Lee, Jayoung, et al.
Publicado: (2017)

Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells
por: Lee, Dae-Hee, et al.
Publicado: (2017)

Concurrent versus Sequential Sorafenib Therapy in Combination with Radiation for Hepatocellular Carcinoma
por: Wild, Aaron T., et al.
Publicado: (2013)

Inhibitory effect of ginsenoside Rg3 on cancer stemness and mesenchymal transition in breast cancer via regulation of myeloid-derived suppressor cells
por: Song, Joong-Hyun, et al.
Publicado: (2020)

Chimeric Antigen Receptor T Cells With Modified Interleukin-13 Preferentially Recognize IL13Rα2 and Suppress Malignant Glioma: A Preclinical Study
por: Kim, Kiwan, et al.
Publicado: (2021)

Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1α and survivin suppression
por: Khalmuratova, Roza, et al.
Publicado: (2018)

O-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Necrotizing fasciitis associated with sorafenib treatment
por: Kang, Ho Won, et al.
Publicado: (2019)

Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis
por: Gong, Eun Ji, et al.
Publicado: (2014)

Lipid raft‐disrupting miltefosine preferentially induces the death of colorectal cancer stem‐like cells
por: Park, So‐Yeon, et al.
Publicado: (2021)

HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy
por: Kim, Chul, et al.
Publicado: (2019)

Feasibility of Sorafenib Combined with Local Radiotherapy in Advanced Hepatocellular Carcinoma
por: Cha, Jihye, et al.
Publicado: (2013)

Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis
por: Liu, Xian-De, et al.
Publicado: (2014)

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
por: Feng, Jiao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rk5t0o9anfmqmbo2k7fmeln1n2