Cargando…

1,25-Dihydroxyvitamin D3 Suppresses TLR8 Expression and TLR8-Mediated Inflammatory Responses in Monocytes In Vitro and Experimental Autoimmune Encephalomyelitis In Vivo

1,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) suppresses autoimmunity and inflammation; however, the mechanism of its action has not been fully understood. We sought in this study to determine whether the anti-immune/anti-inflammatory action of 1,25(OH)(2)D(3) is in part mediated through an interplay b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Bo, Baylink, David J., Deb, Chandra, Zannetti, Claudia, Rajaallah, Fatima, Xing, Weirong, Walter, Michael H., Lau, K.-H. William, Qin, Xuezhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597563/ https://www.ncbi.nlm.nih.gov/pubmed/23516559 http://dx.doi.org/10.1371/journal.pone.0058808

Ejemplares similares

Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis
por: Nguyen, H. Bryant, et al.
Publicado: (2013)

Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis
por: Li, Chih-Huang, et al.
Publicado: (2019)

1,25-Dihydroxyvitamin D(3) Protects against Immune-Mediated Killing of Neurons in Culture and in Experimental Autoimmune Encephalomyelitis
por: Sloka, Scott, et al.
Publicado: (2015)

Primary 1,25-Dihydroxyvitamin D(3) Response of the Interleukin 8 Gene Cluster in Human Monocyte- and Macrophage-Like Cells
por: Ryynänen, Jussi, et al.
Publicado: (2013)

1,25-Dihydroxyvitamin D(3) Inhibits the Differentiation and Migration of T(H)17 Cells to Protect against Experimental Autoimmune Encephalomyelitis
por: Chang, Jae-Hoon, et al.
Publicado: (2010)

Correction: 1,25-Dihydroxyvitamin D(3) Inhibits the Differentiation and Migration of T(H)17 Cells to Protect against Experimental Autoimmune Encephalomyelitis
por: Chang, Jae-Hoon, et al.
Publicado: (2010)

Expression and activation of intracellular receptors TLR7, TLR8 and TLR9 in peripheral blood monocytes from HIV-infected patients
por: Valencia Pacheco, Guillermo J, et al.
Publicado: (2013)

Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
por: Bösl, Korbinian, et al.
Publicado: (2018)

8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D(3)-induced growth inhibition without affecting 1,25-dihydroxyvitamin D(3)-stimulated differentiation of primary mouse epidermal keratinocytes
por: Bollag, Wendy B, et al.
Publicado: (2004)

RNA recognition by human TLR8 can lead to autoimmune inflammation
por: Guiducci, Cristiana, et al.
Publicado: (2013)

Pharmacological Activation of p53 during Human Monocyte to Macrophage Differentiation Attenuates Their Pro-Inflammatory Activation by TLR4, TLR7 and TLR8 Agonists
por: Namgaladze, Dmitry, et al.
Publicado: (2021)

TLR8: No gain, no pain
por: Barrat, Franck J.
Publicado: (2018)

Human CD14(dim) Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
por: Cros, Jérôme, et al.
Publicado: (2010)

Central Nervous System-Endogenous TLR7 and TLR9 Induce Different Immune Responses and Effects on Experimental Autoimmune Encephalomyelitis
por: Dieu, Ruthe Storgaard, et al.
Publicado: (2021)

Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis
por: Wang, Xiaohua, et al.
Publicado: (2016)

Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes
por: Kariuki, Silvia N., et al.
Publicado: (2016)

1,25-Dihydroxyvitamin D3 modulates the phenotype and function of Monocyte derived dendritic cells in cattle
por: Corripio-Miyar, Yolanda, et al.
Publicado: (2017)

R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes
por: Nian, Hua, et al.
Publicado: (2012)

TLR8 escapes X chromosome inactivation in human monocytes and CD4(+) T cells
por: Youness, Ali, et al.
Publicado: (2023)

1,25-Dihydroxyvitamin D(3) Provides Benefits in Vitiligo Based on Modulation of CD8+ T Cell Glycolysis and Function
por: Wei, Yujia, et al.
Publicado: (2023)

TLR8: the forgotten relative revindicated
por: Cervantes, Jorge L, et al.
Publicado: (2012)

The Relevance of TLR8 in Viral Infections
por: Martínez-Espinoza, Iván, et al.
Publicado: (2022)

UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling
por: Itoh, Hiroki, et al.
Publicado: (2011)

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
por: Frega, Giorgio, et al.
Publicado: (2020)

Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs
por: Hung, Yun-Fen, et al.
Publicado: (2018)

Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling
por: Moen, Siv H., et al.
Publicado: (2019)

Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico
por: Posadas-Mondragón, Araceli, et al.
Publicado: (2020)

A Single Naturally Occurring 2’-O-Methylation Converts a TLR7- and TLR8-Activating RNA into a TLR8-Specific Ligand
por: Jung, Stephanie, et al.
Publicado: (2015)

THU233 Reduction Of Overutilization Of 1,25-Dihydroxyvitamin D
por: Brown, Jeremy, et al.
Publicado: (2023)

Vitamin D Binding Protein and Monocyte Response to 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D: Analysis by Mathematical Modeling
por: Chun, Rene F., et al.
Publicado: (2012)

Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis
por: Kwilasz, Andrew J., et al.
Publicado: (2022)

Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes
por: Pang, Maoyin, et al.
Publicado: (2011)

TLR7 and TLR8 Gene Variations and Susceptibility to Hepatitis C Virus Infection
por: Wang, Chiou-Huey, et al.
Publicado: (2011)

Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis
por: Thada, Shruthi, et al.
Publicado: (2021)

Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8)
por: Basole, Chaitali P., et al.
Publicado: (2022)

TLR7/8 in the Pathogenesis of Parkinson’s Disease †
por: Campolo, Michela, et al.
Publicado: (2020)

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3
por: Halicka, H. Dorota, et al.
Publicado: (2012)

Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands
por: Serrano, Ruben, et al.
Publicado: (2021)

TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension
por: Yeh, Fu-Chiang, et al.
Publicado: (2023)

TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis
por: Mellanby, Richard J, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_b3v9bg4fqqb45s0k1kgagqmshg