High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression by Optimized AAV6 Serotype Vectors In Vitro and in a Murine Xenograft Model In Vivo

We have observed that of the 10 AAV serotypes, AAV6 is the most efficient in transducing primary human hematopoietic stem cells (HSCs), and that the transduction efficiency can be further increased by specifically mutating single surface-exposed tyrosine (Y) residues on AAV6 capsids. In the present...

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Detalles Bibliográficos
Autores principales: Song, Liujiang, Li, Xiaomiao, Jayandharan, Giridhara R., Wang, Yuan, Aslanidi, George V., Ling, Chen, Zhong, Li, Gao, Guangping, Yoder, Mervin C., Ling, Changquan, Tan, Mengqun, Srivastava, Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597592/
https://www.ncbi.nlm.nih.gov/pubmed/23516552
http://dx.doi.org/10.1371/journal.pone.0058757

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