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pH-Responsive Artemisinin Derivatives and Lipid Nanoparticle Formulations Inhibit Growth of Breast Cancer Cells In Vitro and Induce Down-Regulation of HER Family Members

Artemisinin (ART) dimers show potent anti-proliferative activities against breast cancer cells. To facilitate their clinical development, novel pH-responsive artemisinin dimers were synthesized for liposomal nanoparticle formulations. A new ART dimer was designed to become increasingly water-soluble...

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Detalles Bibliográficos
Autores principales:	Zhang, Yitong J., Gallis, Byron, Taya, Michio, Wang, Shusheng, Ho, Rodney J. Y., Sasaki, Tomikazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597601/ https://www.ncbi.nlm.nih.gov/pubmed/23516601 http://dx.doi.org/10.1371/journal.pone.0059086

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