Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA

During V(D)J recombination, recombination activating gene (RAG)1 and RAG2 bind and cleave recombination signal sequences (RSSs), aided by the ubiquitous DNA-binding/-bending proteins high-mobility group box protein (HMGB)1 or HMGB2. HMGB1/2 play a critical, although poorly understood, role in vitro...

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Detalles Bibliográficos
Autores principales: Little, Alicia J., Corbett, Elizabeth, Ortega, Fabian, Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597659/
https://www.ncbi.nlm.nih.gov/pubmed/23325855
http://dx.doi.org/10.1093/nar/gks1461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597659/
https://www.ncbi.nlm.nih.gov/pubmed/23325855
http://dx.doi.org/10.1093/nar/gks1461

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