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An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells

Rapid phosphorylation of histone variant H2AX proximal to DNA breaks is an initiating event and a hallmark of eukaryotic DNA damage responses. Three mammalian kinases are known to phosphorylate H2AX in response to DNA damage. However, the mechanism(s) for damage-localized phosphorylation remains inc...

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Detalles Bibliográficos
Autores principales:	Muñoz, Denise P., Kawahara, Misako, Yannone, Steven M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597672/ https://www.ncbi.nlm.nih.gov/pubmed/23325849 http://dx.doi.org/10.1093/nar/gks1478

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