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Lewis acid catalysis of phosphoryl transfer from a copper(II)-NTP complex in a kinase ribozyme

The chemical strategies used by ribozymes to enhance reaction rates are revealed in part from their metal ion and pH requirements. We find that kinase ribozyme K28(1-77)C, in contrast with previously characterized kinase ribozymes, requires Cu(2+) for optimal catalysis of thiophosphoryl transfer fro...

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Detalles Bibliográficos
Autores principales:	Biondi, Elisa, Poudyal, Raghav R., Forgy, Joshua C., Sawyer, Andrew W., Maxwell, Adam W. R., Burke, Donald H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597699/ https://www.ncbi.nlm.nih.gov/pubmed/23358821 http://dx.doi.org/10.1093/nar/gkt039

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