A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis

The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a new small molecule activator, GRN510, with activity ex vivo and in vivo. Using a novel mouse model, w...

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Detalles Bibliográficos
Autores principales: Le Saux, Claude Jourdan, Davy, Philip, Brampton, Christopher, Ahuja, Seema S., Fauce, Steven, Shivshankar, Pooja, Nguyen, Hieu, Ramaseshan, Mahesh, Tressler, Robert, Pirot, Zhu, Harley, Calvin B., Allsopp, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597721/
https://www.ncbi.nlm.nih.gov/pubmed/23516479
http://dx.doi.org/10.1371/journal.pone.0058423

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