N-Substituted Benzyl Matrinic Acid Derivatives Inhibit Hepatitis C Virus (HCV) Replication through Down-Regulating Host Heat-Stress Cognate 70 (Hsc70) Expression

Heat-stress cognate 70 (Hsc70) is a host factor that helps hepatitis C virus (HCV) to complete its life cycle in infected hepatocytes. Using Hsc70 as a target for HCV inhibition, a series of novel N-substituted benzyl matrinic/sophoridinic acid derivatives was synthesized and evaluated for their ant...

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Detalles Bibliográficos
Autores principales: Du, Na-Na, Peng, Zong-Gen, Bi, Chong-Wen, Tang, Sheng, Li, Ying-Hong, Li, Jian-Rui, Zhu, Yan-Ping, Zhang, Jing-Pu, Wang, Yan-Xiang, Jiang, Jian-Dong, Song, Dan-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597726/
https://www.ncbi.nlm.nih.gov/pubmed/23516533
http://dx.doi.org/10.1371/journal.pone.0058675

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