Cargando…

Current status of drug screening and disease modelling in human pluripotent stem cells

The emphasis in human pluripotent stem cell (hPSC) technologies has shifted from cell therapy to in vitro disease modelling and drug screening. This review examines why this shift has occurred, and how current technological limitations might be overcome to fully realise the potential of hPSCs. Detai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajamohan, Divya, Matsa, Elena, Kalra, Spandan, Crutchley, James, Patel, Asha, George, Vinoj, Denning, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2013
Materias:	Prospects & Overviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597971/ https://www.ncbi.nlm.nih.gov/pubmed/22886688 http://dx.doi.org/10.1002/bies.201200053

Ejemplares similares

Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
por: Rajamohan, Divya, et al.
Publicado: (2016)

Modeling heterogeneity in the pluripotent state: A promising strategy for improving the efficiency and fidelity of stem cell differentiation
por: Espinosa Angarica, Vladimir, et al.
Publicado: (2016)

Innovation in biological microscopy: Current status and future directions
por: Swedlow, Jason R
Publicado: (2012)

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform()
por: Denning, Chris, et al.
Publicado: (2016)

Organoids and the genetically encoded self‐assembly of embryonic stem cells
por: Turner, David A., et al.
Publicado: (2015)

The emerging biology of muscle stem cells: Implications for cell-based therapies
por: Bentzinger, C Florian, et al.
Publicado: (2013)

YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage
por: Elbediwy, Ahmed, et al.
Publicado: (2016)

Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
por: Young, George R, et al.
Publicado: (2013)

Keeping your armour intact: How HIV-1 evades detection by the innate immune system
por: Maelfait, Jonathan, et al.
Publicado: (2014)

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
por: Matsa, Elena, et al.
Publicado: (2011)

Mitochondria and the culture of the Borg
por: Braschi, Emelie, et al.
Publicado: (2010)

Orthology prediction methods: A quality assessment using curated protein families
por: Trachana, Kalliopi, et al.
Publicado: (2011)

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models
por: Huijbers, Ivo J, et al.
Publicado: (2011)

Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?
por: Kell, Douglas B
Publicado: (2012)

Long non-coding RNA modifies chromatin: Epigenetic silencing by long non-coding RNAs
por: Saxena, Alka, et al.
Publicado: (2011)

From transporter to transceptor: Signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: Endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function
por: Kriel, Johan, et al.
Publicado: (2011)

Function and evolution of sex determination mechanisms, genes and pathways in insects
por: Gempe, Tanja, et al.
Publicado: (2011)

Upstream open reading frames: Molecular switches in (patho)physiology
por: Wethmar, Klaus, et al.
Publicado: (2010)

Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges
por: Deelen, Joris, et al.
Publicado: (2013)

Population transcriptomics with single-cell resolution: A new field made possible by microfluidics: A technology for high throughput transcript counting and data-driven definition of cell types
por: Plessy, Charles, et al.
Publicado: (2013)

Circadian rhythms and mood: Opportunities for multi-level analyses in genomics and neuroscience
por: Li, Jun Z
Publicado: (2014)

Transfer and functional consequences of dietary microRNAs in vertebrates: Concepts in search of corroboration: Negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist
por: Witwer, Kenneth W, et al.
Publicado: (2014)

Variable escape from X-chromosome inactivation: Identifying factors that tip the scales towards expression
por: Peeters, Samantha B, et al.
Publicado: (2014)

Microtubule dynamic instability: A new model with coupled GTP hydrolysis and multistep catastrophe
por: Bowne-Anderson, Hugo, et al.
Publicado: (2013)

Pausing for thought: Disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis
por: Jennings, Barbara H
Publicado: (2013)

Multi-step down-regulation of the secretory pathway in mitosis: A fresh perspective on protein trafficking
por: Yeong, Foong May
Publicado: (2013)

Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?
por: Nora, Elphège P, et al.
Publicado: (2013)

Stress-induced mutation via DNA breaks in Escherichia coli: A molecular mechanism with implications for evolution and medicine
por: Rosenberg, Susan M, et al.
Publicado: (2012)

A frontier in the understanding of synaptic plasticity: Solving the structure of the postsynaptic density
por: Gold, Matthew G
Publicado: (2012)

Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling
por: Moignard, Victoria, et al.
Publicado: (2014)

Functional interpretation of non-coding sequence variation: Concepts and challenges
por: Paul, Dirk S, et al.
Publicado: (2014)

Modeling and simulation of biological systems from image data
por: Sbalzarini, Ivo F
Publicado: (2013)

Sources of dynamic variability in NF-κB signal transduction: A mechanistic model
por: Mothes, Janina, et al.
Publicado: (2015)

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification
por: Iyer, Lakshminarayan M., et al.
Publicado: (2015)

Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function
por: Dueck, Hannah, et al.
Publicado: (2015)

Mouse models of colorectal cancer as preclinical models
por: McIntyre, Rebecca E., et al.
Publicado: (2015)

Fetal microchimerism and maternal health: A review and evolutionary analysis of cooperation and conflict beyond the womb
por: Boddy, Amy M., et al.
Publicado: (2015)

Luminescent sensing and imaging of oxygen: Fierce competition to the Clark electrode
por: Wolfbeis, Otto S.
Publicado: (2015)

Introns and gene expression: Cellular constraints, transcriptional regulation, and evolutionary consequences
por: Heyn, Patricia, et al.
Publicado: (2015)

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research
por: Hoitzing, Hanne, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e6u1rptg0j082ao00rn5uhe1k5