Deriving dopaminergic neurons for clinical use. A practical approach

New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively charact...

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Detalles Bibliográficos
Autores principales: Gonzalez, Rodolfo, Garitaonandia, Ibon, Abramihina, Tatiana, Wambua, Gerald K., Ostrowska, Alina, Brock, Mathew, Noskov, Alexander, Boscolo, Francesca S., Craw, John S., Laurent, Louise C., Snyder, Evan Y., Semechkin, Ruslan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597995/
https://www.ncbi.nlm.nih.gov/pubmed/23492920
http://dx.doi.org/10.1038/srep01463
Descripción
Sumario:New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.

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