Deriving dopaminergic neurons for clinical use. A practical approach

New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively charact...

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Autores principales: Gonzalez, Rodolfo, Garitaonandia, Ibon, Abramihina, Tatiana, Wambua, Gerald K., Ostrowska, Alina, Brock, Mathew, Noskov, Alexander, Boscolo, Francesca S., Craw, John S., Laurent, Louise C., Snyder, Evan Y., Semechkin, Ruslan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597995/
https://www.ncbi.nlm.nih.gov/pubmed/23492920
http://dx.doi.org/10.1038/srep01463
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author Gonzalez, Rodolfo
Garitaonandia, Ibon
Abramihina, Tatiana
Wambua, Gerald K.
Ostrowska, Alina
Brock, Mathew
Noskov, Alexander
Boscolo, Francesca S.
Craw, John S.
Laurent, Louise C.
Snyder, Evan Y.
Semechkin, Ruslan A.
author_facet Gonzalez, Rodolfo
Garitaonandia, Ibon
Abramihina, Tatiana
Wambua, Gerald K.
Ostrowska, Alina
Brock, Mathew
Noskov, Alexander
Boscolo, Francesca S.
Craw, John S.
Laurent, Louise C.
Snyder, Evan Y.
Semechkin, Ruslan A.
author_sort Gonzalez, Rodolfo
collection PubMed
description New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.
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spelling pubmed-35979952013-03-15 Deriving dopaminergic neurons for clinical use. A practical approach Gonzalez, Rodolfo Garitaonandia, Ibon Abramihina, Tatiana Wambua, Gerald K. Ostrowska, Alina Brock, Mathew Noskov, Alexander Boscolo, Francesca S. Craw, John S. Laurent, Louise C. Snyder, Evan Y. Semechkin, Ruslan A. Sci Rep Article New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients. Nature Publishing Group 2013-03-15 /pmc/articles/PMC3597995/ /pubmed/23492920 http://dx.doi.org/10.1038/srep01463 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Gonzalez, Rodolfo
Garitaonandia, Ibon
Abramihina, Tatiana
Wambua, Gerald K.
Ostrowska, Alina
Brock, Mathew
Noskov, Alexander
Boscolo, Francesca S.
Craw, John S.
Laurent, Louise C.
Snyder, Evan Y.
Semechkin, Ruslan A.
Deriving dopaminergic neurons for clinical use. A practical approach
title Deriving dopaminergic neurons for clinical use. A practical approach
title_full Deriving dopaminergic neurons for clinical use. A practical approach
title_fullStr Deriving dopaminergic neurons for clinical use. A practical approach
title_full_unstemmed Deriving dopaminergic neurons for clinical use. A practical approach
title_short Deriving dopaminergic neurons for clinical use. A practical approach
title_sort deriving dopaminergic neurons for clinical use. a practical approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597995/
https://www.ncbi.nlm.nih.gov/pubmed/23492920
http://dx.doi.org/10.1038/srep01463
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