SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

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Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function in MSCs by creating MSC specific SIRT1 knock-out (MSCKO) mice. Aged MSCKO...

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Detalles Bibliográficos
Autores principales: Simic, Petra, Zainabadi, Kayvan, Bell, Eric, Sykes, David B, Saez, Borja, Lotinun, Sutada, Baron, Roland, Scadden, David, Schipani, Ernestina, Guarente, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598082/
https://www.ncbi.nlm.nih.gov/pubmed/23364955
http://dx.doi.org/10.1002/emmm.201201606
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