Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

ADAM17 and its inhibitor TIMP3 are involved in nephropathy, but their role in diabetic kidney disease (DKD) is unclear. Diabetic Timp3(−/−) mice showed increased albuminuria, increased membrane thickness and mesangial expansion. Microarray profiling uncovered a significant reduction of Foxo1 express...

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Detalles Bibliográficos
Autores principales: Fiorentino, Loredana, Cavalera, Michele, Menini, Stefano, Marchetti, Valentina, Mavilio, Maria, Fabrizi, Marta, Conserva, Francesca, Casagrande, Viviana, Menghini, Rossella, Pontrelli, Paola, Arisi, Ivan, D'Onofrio, Mara, Lauro, Davide, Khokha, Rama, Accili, Domenico, Pugliese, Giuseppe, Gesualdo, Loreto, Lauro, Renato, Federici, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598083/
https://www.ncbi.nlm.nih.gov/pubmed/23401241
http://dx.doi.org/10.1002/emmm.201201475

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