Low-density lipoprotein, its susceptibility to oxidation and the role of lipoprotein-associated phospholipase A(2) and carboxyl ester lipase lipases in atherosclerotic plaque formation

An increased level of low-density lipoprotein (LDL) is a very well established risk factor of coronary artery disease (CAD). Unoxidized LDL is an inert transport vehicle of cholesterol and other lipids in the body and is thought to be atherogenic. Recently it has been appreciated that oxidized products of LDL are responsible for plaque formation properties previously attributed to the intact particle. The goal of this article is to review the recent understanding of the LDL oxidation pathway. The role of oxidized products and key enzymes (lipoprotein-associated phospholipase A(2) and carboxyl ester lipase) are also extensively discussed in the context of clinical conditions.