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Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation

For many years atherosclerosis was believed to be the passive accumulation of cholesterol in vessel walls. Today the picture is more complex, as immune processes occur in atherogenesis. Considerable attention is focused on the particular role of adaptive immune responses orchestrated by T cell subse...

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Autores principales: Chalubinski, Maciej, Wojdan, Katarzyna, Dorantowicz, Roksana, Jackowska, Paulina, Gorzelak, Paulina, Broncel, Marlena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598149/
https://www.ncbi.nlm.nih.gov/pubmed/23515919
http://dx.doi.org/10.5114/aoms.2013.33355
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author Chalubinski, Maciej
Wojdan, Katarzyna
Dorantowicz, Roksana
Jackowska, Paulina
Gorzelak, Paulina
Broncel, Marlena
author_facet Chalubinski, Maciej
Wojdan, Katarzyna
Dorantowicz, Roksana
Jackowska, Paulina
Gorzelak, Paulina
Broncel, Marlena
author_sort Chalubinski, Maciej
collection PubMed
description For many years atherosclerosis was believed to be the passive accumulation of cholesterol in vessel walls. Today the picture is more complex, as immune processes occur in atherogenesis. Considerable attention is focused on the particular role of adaptive immune responses orchestrated by T cell subsets. Since the role of Th1/Th2 balance and Th1 cell domination in atherogenesis is already known, the involvement of regulatory T lymphocytes and recently described Th17 cells raises new concerns. On one hand, each of these cells may specifically drive responses of vascular wall tissues and immune cells; however, they are subject to the control of a plethora of tissue- and pathogen-derived agents. Due to ineffective tissue regeneration, remodeling of the vascular wall occurs. The understanding of the immune regulatory network gives perspectives of innovative immunomodulatory therapies of atherosclerosis and the prevention of its complications, such as coronary artery disease.
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spelling pubmed-35981492013-03-19 Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation Chalubinski, Maciej Wojdan, Katarzyna Dorantowicz, Roksana Jackowska, Paulina Gorzelak, Paulina Broncel, Marlena Arch Med Sci State of the Art Paper For many years atherosclerosis was believed to be the passive accumulation of cholesterol in vessel walls. Today the picture is more complex, as immune processes occur in atherogenesis. Considerable attention is focused on the particular role of adaptive immune responses orchestrated by T cell subsets. Since the role of Th1/Th2 balance and Th1 cell domination in atherogenesis is already known, the involvement of regulatory T lymphocytes and recently described Th17 cells raises new concerns. On one hand, each of these cells may specifically drive responses of vascular wall tissues and immune cells; however, they are subject to the control of a plethora of tissue- and pathogen-derived agents. Due to ineffective tissue regeneration, remodeling of the vascular wall occurs. The understanding of the immune regulatory network gives perspectives of innovative immunomodulatory therapies of atherosclerosis and the prevention of its complications, such as coronary artery disease. Termedia Publishing House 2013-02-21 2013-02-21 /pmc/articles/PMC3598149/ /pubmed/23515919 http://dx.doi.org/10.5114/aoms.2013.33355 Text en Copyright © 2013 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle State of the Art Paper
Chalubinski, Maciej
Wojdan, Katarzyna
Dorantowicz, Roksana
Jackowska, Paulina
Gorzelak, Paulina
Broncel, Marlena
Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
title Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
title_full Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
title_fullStr Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
title_full_unstemmed Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
title_short Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
title_sort comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
topic State of the Art Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598149/
https://www.ncbi.nlm.nih.gov/pubmed/23515919
http://dx.doi.org/10.5114/aoms.2013.33355
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