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The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis

BACKGROUND: Recent studies have demonstrated that myocardial calpain triggers caspase-3 activation and myocardial apoptosis in models of sepsis, whereas the inhibition of calpain activity down-regulates myocardial caspase-3 activation and apoptosis. However, the mechanism underlying this pathologica...

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Detalles Bibliográficos
Autores principales:	Li, Xiaoping, Luo, Rong, Jiang, Rongjian, Meng, Xianmin, Wu, Xiushan, Zhang, Shu, Hua, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598447/ https://www.ncbi.nlm.nih.gov/pubmed/23425388 http://dx.doi.org/10.1186/1471-2261-13-8

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