Cargando…
The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
BACKGROUND: Aging and physical inactivity are associated with declines in some cognitive domains and cerebrovascular function, as well as an elevated risk of cerebrovascular disease and other morbidities. With the increase in the number of sedentary older Canadians, promoting healthy brain aging is...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598522/ https://www.ncbi.nlm.nih.gov/pubmed/23448504 http://dx.doi.org/10.1186/1471-2318-13-21 |
_version_ | 1782262778109624320 |
---|---|
author | Tyndall, Amanda V Davenport, Margie H Wilson, Ben J Burek, Grazyna M Arsenault-Lapierre, Genevieve Haley, Eryka Eskes, Gail A Friedenreich, Christine M Hill, Michael D Hogan, David B Longman, R Stewart Anderson, Todd J Leigh, Richard Smith, Eric E Poulin, Marc J |
author_facet | Tyndall, Amanda V Davenport, Margie H Wilson, Ben J Burek, Grazyna M Arsenault-Lapierre, Genevieve Haley, Eryka Eskes, Gail A Friedenreich, Christine M Hill, Michael D Hogan, David B Longman, R Stewart Anderson, Todd J Leigh, Richard Smith, Eric E Poulin, Marc J |
author_sort | Tyndall, Amanda V |
collection | PubMed |
description | BACKGROUND: Aging and physical inactivity are associated with declines in some cognitive domains and cerebrovascular function, as well as an elevated risk of cerebrovascular disease and other morbidities. With the increase in the number of sedentary older Canadians, promoting healthy brain aging is becoming an increasingly important population health issue. Emerging research suggests that higher levels of physical fitness at any age are associated with better cognitive functioning and this may be mediated, at least in part, by improvements in cerebrovascular reserve. We are currently conducting a study to determine: if a structured 6-month aerobic exercise program is associated with improvements or maintenance of both cerebrovascular function and cognitive abilities in older individuals; and, the extent to which any changes seen persist 6 months after the completion of the structured exercise program. METHODS/DESIGN: Two hundred and fifty men and women aged 55–80 years are being enrolled into an 18-month combined quasi-experimental and prospective cohort study. Participants are eligible for enrollment into the study if they are inactive (i.e., not participating in regular physical activity), non-smokers, have a body mass index <35.0 kg/m(2), are free of significant cognitive impairment (defined as a Montreal Cognitive Assessment score of 24 or more), and do not have clinically significant cardiovascular, cerebrovascular disease, or chronic obstructive pulmonary airway disease. Repeated measurements are done during three sequential six-month phases: 1) pre-intervention; 2) aerobic exercise intervention; and 3) post-intervention. These outcomes include: cardiorespiratory fitness, resting cerebral blood flow, cerebrovascular reserve, and cognitive function. DISCUSSION: This is the first study to our knowledge that will examine contemporaneously the effect of an exercise intervention on both cerebrovascular reserve and cognition in an older population. This study will further our understanding of whether cerebrovascular mechanisms might explain how exercise promotes healthy brain aging. In addition our study will address the potential of increasing physical activity to prevent age-associated cognitive decline. |
format | Online Article Text |
id | pubmed-3598522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35985222013-03-20 The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults Tyndall, Amanda V Davenport, Margie H Wilson, Ben J Burek, Grazyna M Arsenault-Lapierre, Genevieve Haley, Eryka Eskes, Gail A Friedenreich, Christine M Hill, Michael D Hogan, David B Longman, R Stewart Anderson, Todd J Leigh, Richard Smith, Eric E Poulin, Marc J BMC Geriatr Study Protocol BACKGROUND: Aging and physical inactivity are associated with declines in some cognitive domains and cerebrovascular function, as well as an elevated risk of cerebrovascular disease and other morbidities. With the increase in the number of sedentary older Canadians, promoting healthy brain aging is becoming an increasingly important population health issue. Emerging research suggests that higher levels of physical fitness at any age are associated with better cognitive functioning and this may be mediated, at least in part, by improvements in cerebrovascular reserve. We are currently conducting a study to determine: if a structured 6-month aerobic exercise program is associated with improvements or maintenance of both cerebrovascular function and cognitive abilities in older individuals; and, the extent to which any changes seen persist 6 months after the completion of the structured exercise program. METHODS/DESIGN: Two hundred and fifty men and women aged 55–80 years are being enrolled into an 18-month combined quasi-experimental and prospective cohort study. Participants are eligible for enrollment into the study if they are inactive (i.e., not participating in regular physical activity), non-smokers, have a body mass index <35.0 kg/m(2), are free of significant cognitive impairment (defined as a Montreal Cognitive Assessment score of 24 or more), and do not have clinically significant cardiovascular, cerebrovascular disease, or chronic obstructive pulmonary airway disease. Repeated measurements are done during three sequential six-month phases: 1) pre-intervention; 2) aerobic exercise intervention; and 3) post-intervention. These outcomes include: cardiorespiratory fitness, resting cerebral blood flow, cerebrovascular reserve, and cognitive function. DISCUSSION: This is the first study to our knowledge that will examine contemporaneously the effect of an exercise intervention on both cerebrovascular reserve and cognition in an older population. This study will further our understanding of whether cerebrovascular mechanisms might explain how exercise promotes healthy brain aging. In addition our study will address the potential of increasing physical activity to prevent age-associated cognitive decline. BioMed Central 2013-02-28 /pmc/articles/PMC3598522/ /pubmed/23448504 http://dx.doi.org/10.1186/1471-2318-13-21 Text en Copyright ©2013 Tyndall et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Study Protocol Tyndall, Amanda V Davenport, Margie H Wilson, Ben J Burek, Grazyna M Arsenault-Lapierre, Genevieve Haley, Eryka Eskes, Gail A Friedenreich, Christine M Hill, Michael D Hogan, David B Longman, R Stewart Anderson, Todd J Leigh, Richard Smith, Eric E Poulin, Marc J The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults |
title | The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults |
title_full | The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults |
title_fullStr | The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults |
title_full_unstemmed | The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults |
title_short | The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults |
title_sort | brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598522/ https://www.ncbi.nlm.nih.gov/pubmed/23448504 http://dx.doi.org/10.1186/1471-2318-13-21 |
work_keys_str_mv | AT tyndallamandav thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT davenportmargieh thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT wilsonbenj thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT burekgrazynam thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT arsenaultlapierregenevieve thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT haleyeryka thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT eskesgaila thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT friedenreichchristinem thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT hillmichaeld thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT hogandavidb thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT longmanrstewart thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT andersontoddj thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT leighrichard thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT smitherice thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT poulinmarcj thebraininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT tyndallamandav braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT davenportmargieh braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT wilsonbenj braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT burekgrazynam braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT arsenaultlapierregenevieve braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT haleyeryka braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT eskesgaila braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT friedenreichchristinem braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT hillmichaeld braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT hogandavidb braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT longmanrstewart braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT andersontoddj braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT leighrichard braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT smitherice braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults AT poulinmarcj braininmotionstudyeffectofa6monthaerobicexerciseinterventiononcerebrovascularregulationandcognitivefunctioninolderadults |