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The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import

BACKGROUND: HIV-1 is inhibited early after entry into cells expressing some simian orthologues of the tripartite motif protein family member TRIM5α. Mutants of the human orthologue (TRIM5α(hu)) can also provide protection against HIV-1. The host protein cyclophilin A (CypA) binds incoming HIV-1 caps...

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Detalles Bibliográficos
Autores principales:	Veillette, Maxime, Bichel, Katsiaryna, Pawlica, Paulina, Freund, Stefan M V, Plourde, Mélodie B, Pham, Quang Toan, Reyes-Moreno, Carlos, James, Leo C, Berthoux, Lionel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598646/ https://www.ncbi.nlm.nih.gov/pubmed/23448277 http://dx.doi.org/10.1186/1742-4690-10-25

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