Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy

Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr–mediated linezolid resistance among MRSA clinical isolates in ou...

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Detalles Bibliográficos
Autores principales: Sierra, Josep M., Camoez, Mariana, Tubau, Fe, Gasch, Oriol, Pujol, Miquel, Martin, Rogelio, Domínguez, M. Angeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598648/
https://www.ncbi.nlm.nih.gov/pubmed/23554998
http://dx.doi.org/10.1371/journal.pone.0059215
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author Sierra, Josep M.
Camoez, Mariana
Tubau, Fe
Gasch, Oriol
Pujol, Miquel
Martin, Rogelio
Domínguez, M. Angeles
author_facet Sierra, Josep M.
Camoez, Mariana
Tubau, Fe
Gasch, Oriol
Pujol, Miquel
Martin, Rogelio
Domínguez, M. Angeles
author_sort Sierra, Josep M.
collection PubMed
description Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr–mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.
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spelling pubmed-35986482013-04-02 Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy Sierra, Josep M. Camoez, Mariana Tubau, Fe Gasch, Oriol Pujol, Miquel Martin, Rogelio Domínguez, M. Angeles PLoS One Research Article Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr–mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance. Public Library of Science 2013-03-15 /pmc/articles/PMC3598648/ /pubmed/23554998 http://dx.doi.org/10.1371/journal.pone.0059215 Text en © 2013 Sierra et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sierra, Josep M.
Camoez, Mariana
Tubau, Fe
Gasch, Oriol
Pujol, Miquel
Martin, Rogelio
Domínguez, M. Angeles
Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy
title Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy
title_full Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy
title_fullStr Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy
title_full_unstemmed Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy
title_short Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy
title_sort low prevalence of cfr-mediated linezolid resistance among methicillin-resistant staphylococcus aureus in a spanish hospital: case report on linezolid resistance acquired during linezolid therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598648/
https://www.ncbi.nlm.nih.gov/pubmed/23554998
http://dx.doi.org/10.1371/journal.pone.0059215
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