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Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan
BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery. METHODS: An opened randomized, controlled clinical trial was conducted at Soba hospital, S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598675/ https://www.ncbi.nlm.nih.gov/pubmed/23394621 http://dx.doi.org/10.1186/1756-0500-6-57 |
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author | Osman, Bashier Abbas, Amna Ahmed, Mohamed A Abubaker, Magid S Adam, Ishag |
author_facet | Osman, Bashier Abbas, Amna Ahmed, Mohamed A Abubaker, Magid S Adam, Ishag |
author_sort | Osman, Bashier |
collection | PubMed |
description | BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery. METHODS: An opened randomized, controlled clinical trial was conducted at Soba hospital, Sudan to investigate the timing (pre-incision or after clamping of the umbilical cord) of ceftizoxime for elective cesarean delivery. The outcome measures were; the incidence of post-cesarean febrile and infection-related morbidity and neonatal outcomes between the two groups. RESULTS: Hundred –eighty women (90 women in each arm of the study) received intravenous injection of 1 g of ceftizoxime as single dose either at pre-incision or after clamping of the umbilical cord. None of the women in either group had endometritis. One woman in the pre-incision group had chest infection. There was no significant difference in the incidence of wound infection between the two groups, 8 (6.7%) vs. 3 (3.3%); P = 0.2. Two babies in the pre-incision group (P = 0.497) had a low Apgar score (< 8) at 1 min. Similar number of neonate (15 in each arm) was admitted to nursery. There were no significant difference in the neonatal jaundice between the two groups, 5 (5.5%) vs. 4 (4.4%), P = 0.2. There was no perinatal death. CONCLUSIONS: There was no difference in the two regimens (pre-incision or post-clamping of the umbilical cord) of ceftizoxime as prophylactic for elective cesarean delivery. TRIAL REGISTRATION: NCT01347593 |
format | Online Article Text |
id | pubmed-3598675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35986752013-03-16 Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan Osman, Bashier Abbas, Amna Ahmed, Mohamed A Abubaker, Magid S Adam, Ishag BMC Res Notes Research Article BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery. METHODS: An opened randomized, controlled clinical trial was conducted at Soba hospital, Sudan to investigate the timing (pre-incision or after clamping of the umbilical cord) of ceftizoxime for elective cesarean delivery. The outcome measures were; the incidence of post-cesarean febrile and infection-related morbidity and neonatal outcomes between the two groups. RESULTS: Hundred –eighty women (90 women in each arm of the study) received intravenous injection of 1 g of ceftizoxime as single dose either at pre-incision or after clamping of the umbilical cord. None of the women in either group had endometritis. One woman in the pre-incision group had chest infection. There was no significant difference in the incidence of wound infection between the two groups, 8 (6.7%) vs. 3 (3.3%); P = 0.2. Two babies in the pre-incision group (P = 0.497) had a low Apgar score (< 8) at 1 min. Similar number of neonate (15 in each arm) was admitted to nursery. There were no significant difference in the neonatal jaundice between the two groups, 5 (5.5%) vs. 4 (4.4%), P = 0.2. There was no perinatal death. CONCLUSIONS: There was no difference in the two regimens (pre-incision or post-clamping of the umbilical cord) of ceftizoxime as prophylactic for elective cesarean delivery. TRIAL REGISTRATION: NCT01347593 BioMed Central 2013-02-08 /pmc/articles/PMC3598675/ /pubmed/23394621 http://dx.doi.org/10.1186/1756-0500-6-57 Text en Copyright ©2013 Osman et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Osman, Bashier Abbas, Amna Ahmed, Mohamed A Abubaker, Magid S Adam, Ishag Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan |
title | Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan |
title_full | Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan |
title_fullStr | Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan |
title_full_unstemmed | Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan |
title_short | Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan |
title_sort | prophylactic ceftizoxime for elective cesarean delivery at soba hospital, sudan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598675/ https://www.ncbi.nlm.nih.gov/pubmed/23394621 http://dx.doi.org/10.1186/1756-0500-6-57 |
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