Cargando…

Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan

BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery. METHODS: An opened randomized, controlled clinical trial was conducted at Soba hospital, S...

Descripción completa

Detalles Bibliográficos
Autores principales: Osman, Bashier, Abbas, Amna, Ahmed, Mohamed A, Abubaker, Magid S, Adam, Ishag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598675/
https://www.ncbi.nlm.nih.gov/pubmed/23394621
http://dx.doi.org/10.1186/1756-0500-6-57
_version_ 1782262797760987136
author Osman, Bashier
Abbas, Amna
Ahmed, Mohamed A
Abubaker, Magid S
Adam, Ishag
author_facet Osman, Bashier
Abbas, Amna
Ahmed, Mohamed A
Abubaker, Magid S
Adam, Ishag
author_sort Osman, Bashier
collection PubMed
description BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery. METHODS: An opened randomized, controlled clinical trial was conducted at Soba hospital, Sudan to investigate the timing (pre-incision or after clamping of the umbilical cord) of ceftizoxime for elective cesarean delivery. The outcome measures were; the incidence of post-cesarean febrile and infection-related morbidity and neonatal outcomes between the two groups. RESULTS: Hundred –eighty women (90 women in each arm of the study) received intravenous injection of 1 g of ceftizoxime as single dose either at pre-incision or after clamping of the umbilical cord. None of the women in either group had endometritis. One woman in the pre-incision group had chest infection. There was no significant difference in the incidence of wound infection between the two groups, 8 (6.7%) vs. 3 (3.3%); P = 0.2. Two babies in the pre-incision group (P = 0.497) had a low Apgar score (< 8) at 1 min. Similar number of neonate (15 in each arm) was admitted to nursery. There were no significant difference in the neonatal jaundice between the two groups, 5 (5.5%) vs. 4 (4.4%), P = 0.2. There was no perinatal death. CONCLUSIONS: There was no difference in the two regimens (pre-incision or post-clamping of the umbilical cord) of ceftizoxime as prophylactic for elective cesarean delivery. TRIAL REGISTRATION: NCT01347593
format Online
Article
Text
id pubmed-3598675
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-35986752013-03-16 Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan Osman, Bashier Abbas, Amna Ahmed, Mohamed A Abubaker, Magid S Adam, Ishag BMC Res Notes Research Article BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery. METHODS: An opened randomized, controlled clinical trial was conducted at Soba hospital, Sudan to investigate the timing (pre-incision or after clamping of the umbilical cord) of ceftizoxime for elective cesarean delivery. The outcome measures were; the incidence of post-cesarean febrile and infection-related morbidity and neonatal outcomes between the two groups. RESULTS: Hundred –eighty women (90 women in each arm of the study) received intravenous injection of 1 g of ceftizoxime as single dose either at pre-incision or after clamping of the umbilical cord. None of the women in either group had endometritis. One woman in the pre-incision group had chest infection. There was no significant difference in the incidence of wound infection between the two groups, 8 (6.7%) vs. 3 (3.3%); P = 0.2. Two babies in the pre-incision group (P = 0.497) had a low Apgar score (< 8) at 1 min. Similar number of neonate (15 in each arm) was admitted to nursery. There were no significant difference in the neonatal jaundice between the two groups, 5 (5.5%) vs. 4 (4.4%), P = 0.2. There was no perinatal death. CONCLUSIONS: There was no difference in the two regimens (pre-incision or post-clamping of the umbilical cord) of ceftizoxime as prophylactic for elective cesarean delivery. TRIAL REGISTRATION: NCT01347593 BioMed Central 2013-02-08 /pmc/articles/PMC3598675/ /pubmed/23394621 http://dx.doi.org/10.1186/1756-0500-6-57 Text en Copyright ©2013 Osman et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Osman, Bashier
Abbas, Amna
Ahmed, Mohamed A
Abubaker, Magid S
Adam, Ishag
Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan
title Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan
title_full Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan
title_fullStr Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan
title_full_unstemmed Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan
title_short Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan
title_sort prophylactic ceftizoxime for elective cesarean delivery at soba hospital, sudan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598675/
https://www.ncbi.nlm.nih.gov/pubmed/23394621
http://dx.doi.org/10.1186/1756-0500-6-57
work_keys_str_mv AT osmanbashier prophylacticceftizoximeforelectivecesareandeliveryatsobahospitalsudan
AT abbasamna prophylacticceftizoximeforelectivecesareandeliveryatsobahospitalsudan
AT ahmedmohameda prophylacticceftizoximeforelectivecesareandeliveryatsobahospitalsudan
AT abubakermagids prophylacticceftizoximeforelectivecesareandeliveryatsobahospitalsudan
AT adamishag prophylacticceftizoximeforelectivecesareandeliveryatsobahospitalsudan