Cargando…

Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection

BACKGROUND: Type I interferon (IFN) treatment of some cells, including dendritic cells, macrophages and monocytic THP-1 cells, restricts HIV-1 infection and prevents viral cDNA accumulation. Sterile alpha motif and HD domain protein 1 (SAMHD1), a dGTP-regulated deoxynucleotide triphosphohydrolase, r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goujon, Caroline, Schaller, Torsten, Galão, Rui Pedro, Amie, Sarah M, Kim, Baek, Olivieri, Kevin, Neil, Stuart JD, Malim, Michael H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598776/ https://www.ncbi.nlm.nih.gov/pubmed/23442224 http://dx.doi.org/10.1186/1742-4690-10-23

Ejemplares similares

Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to Vpx(MAC) induced ubiquitination and proteasomal degradation
por: Schaller, Torsten, et al.
Publicado: (2014)

SAMHD1 is a barrier to antimetabolite-based cancer therapies
por: Rudd, Sean G., et al.
Publicado: (2017)

Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2013)

Substrates and Inhibitors of SAMHD1
por: Hollenbaugh, Joseph A., et al.
Publicado: (2017)

Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors
por: Bulli, Lorenzo, et al.
Publicado: (2016)

SAMHD1 Functions and Human Diseases
por: Coggins, Si’Ana A., et al.
Publicado: (2020)

New insights into an X-traordinary viral protein
por: Schaller, Torsten, et al.
Publicado: (2014)

Restriction of diverse retroviruses by SAMHD1
por: Gramberg, Thomas, et al.
Publicado: (2013)

Evidence that HIV-1 restriction factor SAMHD1 facilitates differentiation of myeloid THP-1 cells
por: Dragin, Loic, et al.
Publicado: (2015)

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites
por: Herold, Nikolas, et al.
Publicado: (2017)

Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses
por: Galão, Rui Pedro, et al.
Publicado: (2012)

Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells
por: Hollenbaugh, Joseph A., et al.
Publicado: (2013)

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein
por: Fujita, Mikako, et al.
Publicado: (2012)

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
por: Herrmann, Alexandra, et al.
Publicado: (2018)

Retroviral Retention Activates a Syk-Dependent HemITAM in Human Tetherin
por: Galão, Rui Pedro, et al.
Publicado: (2014)

Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection
por: Cingöz, Oya, et al.
Publicado: (2021)

The SAMHD1 rs6029941 (A/G) Polymorphism Seems to Influence the HTLV-1 Proviral Load and IFN-Alpha Levels
por: Queiroz, Maria Alice Freitas, et al.
Publicado: (2020)

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia
por: Johansson, Patricia, et al.
Publicado: (2018)

SAMHD1 prevents autoimmunity by maintaining genome stability
por: Kretschmer, Stefanie, et al.
Publicado: (2015)

SAMHD1 … and Viral Ways around It
por: Deutschmann, Janina, et al.
Publicado: (2021)

SAMHD1 in cancer: curse or cure?
por: Schott, Kerstin, et al.
Publicado: (2021)

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection
por: Goujon, Caroline, et al.
Publicado: (2013)

Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
por: Plitnik, Timothy, et al.
Publicado: (2018)

A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages
por: Mlcochova, Petra, et al.
Publicado: (2017)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection
por: Fu, Weihui, et al.
Publicado: (2016)

Regulation of IFNα-induced expression of the short ACE2 isoform by ULK1
por: Perez, Ricardo E., et al.
Publicado: (2022)

Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy
por: Rudd, Sean G, et al.
Publicado: (2020)

Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway
por: Ren, Huiling, et al.
Publicado: (2020)

SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells
por: Zhang, Ruonan, et al.
Publicado: (2014)

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
por: Mahboubi, Bijan, et al.
Publicado: (2018)

Interferon-α blocks HIV-1 infection in non-dividing myeloid cells despite SAMHD1 degradation and high deoxynucleoside triphosphates supply
por: Dragin, Loic, et al.
Publicado: (2013)

Spontaneous Type I IFN response in SAMHD1-deficient mice requires both, functional intracellular RNA and DNA sensing pathways
por: Behrendt, R, et al.
Publicado: (2015)

KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides
por: Ficarelli, Mattia, et al.
Publicado: (2019)

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle
por: Sommer, Andreas F. R., et al.
Publicado: (2016)

Mechanism of Allosteric Activation of SAMHD1 by dGTP
por: Ji, Xiaoyun, et al.
Publicado: (2013)

Molecular mechanisms of the interplay between Vpx and SAMHD1
por: Wu, Ying, et al.
Publicado: (2013)

SAMHD1-dependent retroviral control and escape in mice
por: Rehwinkel, Jan, et al.
Publicado: (2013)

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4(+) T-lymphocytes cannot be upregulated by interferons
por: St Gelais, Corine, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9i7o0sai2ppgmlg8n7k5pamufo