Cargando…

Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis

OBJECTIVE: Whilst regular exercise is advocated for people with type 1 diabetes, the benefits of this therapy are poorly delineated. Our objective was to review the evidence for a glycaemic benefit of exercise in type 1 diabetes. RESEARCH DESIGN AND METHODS: Electronic database searches were carried...

Descripción completa

Detalles Bibliográficos
Autores principales: Kennedy, Amy, Nirantharakumar, Krishnarajah, Chimen, Myriam, Pang, Terence T., Hemming, Karla, Andrews, Rob C., Narendran, Parth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598953/
https://www.ncbi.nlm.nih.gov/pubmed/23554942
http://dx.doi.org/10.1371/journal.pone.0058861
_version_ 1782262857930375168
author Kennedy, Amy
Nirantharakumar, Krishnarajah
Chimen, Myriam
Pang, Terence T.
Hemming, Karla
Andrews, Rob C.
Narendran, Parth
author_facet Kennedy, Amy
Nirantharakumar, Krishnarajah
Chimen, Myriam
Pang, Terence T.
Hemming, Karla
Andrews, Rob C.
Narendran, Parth
author_sort Kennedy, Amy
collection PubMed
description OBJECTIVE: Whilst regular exercise is advocated for people with type 1 diabetes, the benefits of this therapy are poorly delineated. Our objective was to review the evidence for a glycaemic benefit of exercise in type 1 diabetes. RESEARCH DESIGN AND METHODS: Electronic database searches were carried out in MEDLINE, Embase, Cochrane’s Controlled Trials Register and SPORTDiscus. In addition, we searched for as yet unpublished but completed trials. Glycaemic benefit was defined as an improvement in glycosylated haemoglobin (HbA1c). Both randomised and non-randomised controlled trials were included. RESULTS: Thirteen studies were identified in the systematic review. Meta-analysis of twelve of these (including 452 patients) demonstrated an HbA1c reduction but this was not statistically significant (standardised mean difference (SMD) −0.25; 95% CI, −0.59 to 0.09). CONCLUSIONS: This meta-analysis does not reveal evidence for a glycaemic benefit of exercise as measured by HbA1c. Reasons for this finding could include increased calorie intake, insulin dose reductions around the time of exercise or lack of power. We also suggest that HbA1c may not be a sensitive indicator of glycaemic control, and that improvement in glycaemic variability may not be reflected in this measure. Exercise does however have other proven benefits in type 1 diabetes, and remains an important part of its management.
format Online
Article
Text
id pubmed-3598953
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-35989532013-04-02 Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis Kennedy, Amy Nirantharakumar, Krishnarajah Chimen, Myriam Pang, Terence T. Hemming, Karla Andrews, Rob C. Narendran, Parth PLoS One Research Article OBJECTIVE: Whilst regular exercise is advocated for people with type 1 diabetes, the benefits of this therapy are poorly delineated. Our objective was to review the evidence for a glycaemic benefit of exercise in type 1 diabetes. RESEARCH DESIGN AND METHODS: Electronic database searches were carried out in MEDLINE, Embase, Cochrane’s Controlled Trials Register and SPORTDiscus. In addition, we searched for as yet unpublished but completed trials. Glycaemic benefit was defined as an improvement in glycosylated haemoglobin (HbA1c). Both randomised and non-randomised controlled trials were included. RESULTS: Thirteen studies were identified in the systematic review. Meta-analysis of twelve of these (including 452 patients) demonstrated an HbA1c reduction but this was not statistically significant (standardised mean difference (SMD) −0.25; 95% CI, −0.59 to 0.09). CONCLUSIONS: This meta-analysis does not reveal evidence for a glycaemic benefit of exercise as measured by HbA1c. Reasons for this finding could include increased calorie intake, insulin dose reductions around the time of exercise or lack of power. We also suggest that HbA1c may not be a sensitive indicator of glycaemic control, and that improvement in glycaemic variability may not be reflected in this measure. Exercise does however have other proven benefits in type 1 diabetes, and remains an important part of its management. Public Library of Science 2013-03-15 /pmc/articles/PMC3598953/ /pubmed/23554942 http://dx.doi.org/10.1371/journal.pone.0058861 Text en © 2013 Kennedy et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kennedy, Amy
Nirantharakumar, Krishnarajah
Chimen, Myriam
Pang, Terence T.
Hemming, Karla
Andrews, Rob C.
Narendran, Parth
Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis
title Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis
title_full Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis
title_fullStr Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis
title_full_unstemmed Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis
title_short Does Exercise Improve Glycaemic Control in Type 1 Diabetes? A Systematic Review and Meta-Analysis
title_sort does exercise improve glycaemic control in type 1 diabetes? a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598953/
https://www.ncbi.nlm.nih.gov/pubmed/23554942
http://dx.doi.org/10.1371/journal.pone.0058861
work_keys_str_mv AT kennedyamy doesexerciseimproveglycaemiccontrolintype1diabetesasystematicreviewandmetaanalysis
AT nirantharakumarkrishnarajah doesexerciseimproveglycaemiccontrolintype1diabetesasystematicreviewandmetaanalysis
AT chimenmyriam doesexerciseimproveglycaemiccontrolintype1diabetesasystematicreviewandmetaanalysis
AT pangterencet doesexerciseimproveglycaemiccontrolintype1diabetesasystematicreviewandmetaanalysis
AT hemmingkarla doesexerciseimproveglycaemiccontrolintype1diabetesasystematicreviewandmetaanalysis
AT andrewsrobc doesexerciseimproveglycaemiccontrolintype1diabetesasystematicreviewandmetaanalysis
AT narendranparth doesexerciseimproveglycaemiccontrolintype1diabetesasystematicreviewandmetaanalysis