Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age

This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed usi...

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Autores principales: Sakowicz, Agata, Fendler, Wojciech, Lelonek, Malgorzata, Sakowicz, Bartosz, Pietrucha, Tadeusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599159/
https://www.ncbi.nlm.nih.gov/pubmed/23274712
http://dx.doi.org/10.1007/s10528-012-9558-5
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author Sakowicz, Agata
Fendler, Wojciech
Lelonek, Malgorzata
Sakowicz, Bartosz
Pietrucha, Tadeusz
author_facet Sakowicz, Agata
Fendler, Wojciech
Lelonek, Malgorzata
Sakowicz, Bartosz
Pietrucha, Tadeusz
author_sort Sakowicz, Agata
collection PubMed
description This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR–RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups.
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spelling pubmed-35991592013-03-19 Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age Sakowicz, Agata Fendler, Wojciech Lelonek, Malgorzata Sakowicz, Bartosz Pietrucha, Tadeusz Biochem Genet Article This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR–RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups. Springer US 2012-12-30 2013 /pmc/articles/PMC3599159/ /pubmed/23274712 http://dx.doi.org/10.1007/s10528-012-9558-5 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Sakowicz, Agata
Fendler, Wojciech
Lelonek, Malgorzata
Sakowicz, Bartosz
Pietrucha, Tadeusz
Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age
title Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age
title_full Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age
title_fullStr Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age
title_full_unstemmed Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age
title_short Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age
title_sort genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599159/
https://www.ncbi.nlm.nih.gov/pubmed/23274712
http://dx.doi.org/10.1007/s10528-012-9558-5
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