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Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study

BACKGROUND: Surgery plays a key role in HIV palliative care, specifically in the diagnosis and treatment of HIV related and non-related conditions. Yet major surgery depresses the immune system. Whereas the surgical consequences of HIV infection are well described, there is a paucity of published da...

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Autores principales: Okumu, Gabriel, Makobore, Patson, Kaggwa, Sam, Kambugu, Andrew, Galukande, Moses
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599316/
https://www.ncbi.nlm.nih.gov/pubmed/23442732
http://dx.doi.org/10.1186/1471-2482-13-4
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author Okumu, Gabriel
Makobore, Patson
Kaggwa, Sam
Kambugu, Andrew
Galukande, Moses
author_facet Okumu, Gabriel
Makobore, Patson
Kaggwa, Sam
Kambugu, Andrew
Galukande, Moses
author_sort Okumu, Gabriel
collection PubMed
description BACKGROUND: Surgery plays a key role in HIV palliative care, specifically in the diagnosis and treatment of HIV related and non-related conditions. Yet major surgery depresses the immune system. Whereas the surgical consequences of HIV infection are well described, there is a paucity of published data, in resource-limited settings, on the effects of major surgery on the immune system. The purpose of this study was to determine the effect of major abdominal surgery on CD4 count in HIV positive and HIV negative patients after emergency major surgery. METHODS: A prospective cohort study was done for patients who underwent emergency major abdominal surgery. Their peri-operative CD4 counts were done for both HIV- and HIV + patients. Median CD4s were used in analysis. Mann Whitney test of significance was used for continuous data and Fisher’ exact test used for categorical data. IRB approval was obtained. RESULTS: A total of 101 patients were recruited, 25 HIV positive and 76 HIV negative. The median CD4 cell reduction was higher in the HIV negative group (−68 cells) than HIV positive group (−29 cells) (p = 0.480). There was a general increase in the median CD4 change by 72 cells for the HIV positives and 95 cells for the HIV negatives (p = 0.44). CD4 change rose in both the HIV positive and negative groups by 27 cells for the HIV positives and 28 cells for the HIV negatives (p = 0.94). Relative Risk was 0.96, {CI 0.60 – 1.53}. CONCLUSION: Major emergency abdominal surgery had no significant effect on CD4 cell count among HIV positive patients.
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spelling pubmed-35993162013-03-17 Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study Okumu, Gabriel Makobore, Patson Kaggwa, Sam Kambugu, Andrew Galukande, Moses BMC Surg Research Article BACKGROUND: Surgery plays a key role in HIV palliative care, specifically in the diagnosis and treatment of HIV related and non-related conditions. Yet major surgery depresses the immune system. Whereas the surgical consequences of HIV infection are well described, there is a paucity of published data, in resource-limited settings, on the effects of major surgery on the immune system. The purpose of this study was to determine the effect of major abdominal surgery on CD4 count in HIV positive and HIV negative patients after emergency major surgery. METHODS: A prospective cohort study was done for patients who underwent emergency major abdominal surgery. Their peri-operative CD4 counts were done for both HIV- and HIV + patients. Median CD4s were used in analysis. Mann Whitney test of significance was used for continuous data and Fisher’ exact test used for categorical data. IRB approval was obtained. RESULTS: A total of 101 patients were recruited, 25 HIV positive and 76 HIV negative. The median CD4 cell reduction was higher in the HIV negative group (−68 cells) than HIV positive group (−29 cells) (p = 0.480). There was a general increase in the median CD4 change by 72 cells for the HIV positives and 95 cells for the HIV negatives (p = 0.44). CD4 change rose in both the HIV positive and negative groups by 27 cells for the HIV positives and 28 cells for the HIV negatives (p = 0.94). Relative Risk was 0.96, {CI 0.60 – 1.53}. CONCLUSION: Major emergency abdominal surgery had no significant effect on CD4 cell count among HIV positive patients. BioMed Central 2013-02-26 /pmc/articles/PMC3599316/ /pubmed/23442732 http://dx.doi.org/10.1186/1471-2482-13-4 Text en Copyright ©2013 Okumu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Okumu, Gabriel
Makobore, Patson
Kaggwa, Sam
Kambugu, Andrew
Galukande, Moses
Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study
title Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study
title_full Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study
title_fullStr Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study
title_full_unstemmed Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study
title_short Effect of emergency major abdominal surgery on CD4 cell count among HIV positive patients in a sub Saharan Africa tertiary hospital - a prospective study
title_sort effect of emergency major abdominal surgery on cd4 cell count among hiv positive patients in a sub saharan africa tertiary hospital - a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599316/
https://www.ncbi.nlm.nih.gov/pubmed/23442732
http://dx.doi.org/10.1186/1471-2482-13-4
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