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The illusion of specific capture: surface and solution studies of suboptimal oligonucleotide hybridization
BACKGROUND: Hybridization based assays and capture systems depend on the specificity of hybridization between a probe and its intended target. A common guideline in the construction of DNA microarrays, for instance, is that avoiding complementary stretches of more than 15 nucleic acids in a 50 or 60...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599332/ https://www.ncbi.nlm.nih.gov/pubmed/23445545 http://dx.doi.org/10.1186/1756-0500-6-72 |