Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis

BACKGROUND: The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research of this plant during growth is necessary. RESULTS: Principal component analysis of the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. The chemical mark...

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Detalles Bibliográficos
Autores principales: Qian, Yiyun, Wang, Yali, Sa, Rina, Yan, Hui, Pan, Xinbo, Yang, Yingwen, Sun, Yujing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599347/
https://www.ncbi.nlm.nih.gov/pubmed/23453085
http://dx.doi.org/10.1186/1752-153X-7-42
Descripción
Sumario:BACKGROUND: The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research of this plant during growth is necessary. RESULTS: Principal component analysis of the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. The chemical markers accounting for these separations were identified from the PCA loadings plot. These markers were further verified by accurate mass tandem mass and retention times of available reference standards. The study has shown that accumulation of secondary metabolites of Angelica sinensis is closely related to the growth periods. CONCLUSIONS: The UPLC-QTOFMS based metabolomics approach has great potential for analysis of the alterations of secondary metabolites of Angelica sinensis during growth.

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