Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis

BACKGROUND: The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research of this plant during growth is necessary. RESULTS: Principal component analysis of the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. The chemical mark...

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Autores principales: Qian, Yiyun, Wang, Yali, Sa, Rina, Yan, Hui, Pan, Xinbo, Yang, Yingwen, Sun, Yujing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599347/
https://www.ncbi.nlm.nih.gov/pubmed/23453085
http://dx.doi.org/10.1186/1752-153X-7-42
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author Qian, Yiyun
Wang, Yali
Sa, Rina
Yan, Hui
Pan, Xinbo
Yang, Yingwen
Sun, Yujing
author_facet Qian, Yiyun
Wang, Yali
Sa, Rina
Yan, Hui
Pan, Xinbo
Yang, Yingwen
Sun, Yujing
author_sort Qian, Yiyun
collection PubMed
description BACKGROUND: The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research of this plant during growth is necessary. RESULTS: Principal component analysis of the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. The chemical markers accounting for these separations were identified from the PCA loadings plot. These markers were further verified by accurate mass tandem mass and retention times of available reference standards. The study has shown that accumulation of secondary metabolites of Angelica sinensis is closely related to the growth periods. CONCLUSIONS: The UPLC-QTOFMS based metabolomics approach has great potential for analysis of the alterations of secondary metabolites of Angelica sinensis during growth.
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spelling pubmed-35993472013-03-17 Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis Qian, Yiyun Wang, Yali Sa, Rina Yan, Hui Pan, Xinbo Yang, Yingwen Sun, Yujing Chem Cent J Research Article BACKGROUND: The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research of this plant during growth is necessary. RESULTS: Principal component analysis of the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. The chemical markers accounting for these separations were identified from the PCA loadings plot. These markers were further verified by accurate mass tandem mass and retention times of available reference standards. The study has shown that accumulation of secondary metabolites of Angelica sinensis is closely related to the growth periods. CONCLUSIONS: The UPLC-QTOFMS based metabolomics approach has great potential for analysis of the alterations of secondary metabolites of Angelica sinensis during growth. BioMed Central 2013-03-01 /pmc/articles/PMC3599347/ /pubmed/23453085 http://dx.doi.org/10.1186/1752-153X-7-42 Text en Copyright ©2013 Qian et al; licensee Chemistry Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qian, Yiyun
Wang, Yali
Sa, Rina
Yan, Hui
Pan, Xinbo
Yang, Yingwen
Sun, Yujing
Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis
title Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis
title_full Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis
title_fullStr Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis
title_full_unstemmed Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis
title_short Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis
title_sort metabolic fingerprinting of angelica sinensis during growth using uplc-tofms and chemometrics data analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599347/
https://www.ncbi.nlm.nih.gov/pubmed/23453085
http://dx.doi.org/10.1186/1752-153X-7-42
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