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Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents

A near-infrared (NIR)-responsive Au(rod)@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The...

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Autores principales: Shang, Ting, Wang, Cai-ding, Ren, Lei, Tian, Xin-hua, Li, Dong-hui, Ke, Xue-bin, Chen, Min, Yang, An-qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599406/
https://www.ncbi.nlm.nih.gov/pubmed/23279853
http://dx.doi.org/10.1186/1556-276X-8-4
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author Shang, Ting
Wang, Cai-ding
Ren, Lei
Tian, Xin-hua
Li, Dong-hui
Ke, Xue-bin
Chen, Min
Yang, An-qi
author_facet Shang, Ting
Wang, Cai-ding
Ren, Lei
Tian, Xin-hua
Li, Dong-hui
Ke, Xue-bin
Chen, Min
Yang, An-qi
author_sort Shang, Ting
collection PubMed
description A near-infrared (NIR)-responsive Au(rod)@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Au(rod)@pNIPAAm-PEGMA nanogel were characterized by UV–vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Au(rod)@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Au(rod)@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc(4)) as a drug model. It was also demonstrated that the loaded ZnPc(4) could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Au(rod)@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy.
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spelling pubmed-35994062013-03-19 Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents Shang, Ting Wang, Cai-ding Ren, Lei Tian, Xin-hua Li, Dong-hui Ke, Xue-bin Chen, Min Yang, An-qi Nanoscale Res Lett Nano Express A near-infrared (NIR)-responsive Au(rod)@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Au(rod)@pNIPAAm-PEGMA nanogel were characterized by UV–vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Au(rod)@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Au(rod)@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc(4)) as a drug model. It was also demonstrated that the loaded ZnPc(4) could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Au(rod)@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy. Springer 2013-01-02 /pmc/articles/PMC3599406/ /pubmed/23279853 http://dx.doi.org/10.1186/1556-276X-8-4 Text en Copyright ©2013 Shang et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nano Express
Shang, Ting
Wang, Cai-ding
Ren, Lei
Tian, Xin-hua
Li, Dong-hui
Ke, Xue-bin
Chen, Min
Yang, An-qi
Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
title Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
title_full Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
title_fullStr Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
title_full_unstemmed Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
title_short Synthesis and characterization of NIR-responsive Au(rod)@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
title_sort synthesis and characterization of nir-responsive au(rod)@pnipaam-pegma nanogels as vehicles for delivery of photodynamic therapy agents
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599406/
https://www.ncbi.nlm.nih.gov/pubmed/23279853
http://dx.doi.org/10.1186/1556-276X-8-4
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