Atypical rearrangement involving 3′-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression

The t(8;14)(q24.1;q32), the cytogenetic hallmark of Burkitt’s lymphoma, is also found, but rarely, in cases of chronic lymphocytic leukemia (CLL). Such translocation typically results in a MYC-IGH@ fusion subsequently deregulating and overexpressing MYC on der 14q32. In CLL, atypical rearrangements...

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Detalles Bibliográficos
Autores principales: Amarillo, Ina, Bui, Peter H, Kantarci, Sibel, Rao, Nagesh, Shackley, Brit S, García, Rolando, Tirado, Carlos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599416/
https://www.ncbi.nlm.nih.gov/pubmed/23369149
http://dx.doi.org/10.1186/1755-8166-6-5

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