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Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

BACKGROUND: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce. METHODS: Surrogate markers of S...

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Autores principales: Won, Ki-Bum, Chang, Hyuk-Jae, Kim, Hyeon-Chang, Jeon, Kyewon, Lee, Hancheol, Shin, Sanghoon, Cho, In-Jeong, Park, Sung-Ha, Lee, Sang-Hak, Jang, Yangsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599532/
https://www.ncbi.nlm.nih.gov/pubmed/23452437
http://dx.doi.org/10.1186/1475-2840-12-41
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author Won, Ki-Bum
Chang, Hyuk-Jae
Kim, Hyeon-Chang
Jeon, Kyewon
Lee, Hancheol
Shin, Sanghoon
Cho, In-Jeong
Park, Sung-Ha
Lee, Sang-Hak
Jang, Yangsoo
author_facet Won, Ki-Bum
Chang, Hyuk-Jae
Kim, Hyeon-Chang
Jeon, Kyewon
Lee, Hancheol
Shin, Sanghoon
Cho, In-Jeong
Park, Sung-Ha
Lee, Sang-Hak
Jang, Yangsoo
author_sort Won, Ki-Bum
collection PubMed
description BACKGROUND: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce. METHODS: Surrogate markers of SCA, brachial–ankle pulse wave velocity (baPWV), and carotid intima–medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study. RESULTS: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002). CONCLUSIONS: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.
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spelling pubmed-35995322013-03-17 Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes Won, Ki-Bum Chang, Hyuk-Jae Kim, Hyeon-Chang Jeon, Kyewon Lee, Hancheol Shin, Sanghoon Cho, In-Jeong Park, Sung-Ha Lee, Sang-Hak Jang, Yangsoo Cardiovasc Diabetol Original Investigation BACKGROUND: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce. METHODS: Surrogate markers of SCA, brachial–ankle pulse wave velocity (baPWV), and carotid intima–medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study. RESULTS: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002). CONCLUSIONS: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals. BioMed Central 2013-03-04 /pmc/articles/PMC3599532/ /pubmed/23452437 http://dx.doi.org/10.1186/1475-2840-12-41 Text en Copyright ©2013 Won et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Investigation
Won, Ki-Bum
Chang, Hyuk-Jae
Kim, Hyeon-Chang
Jeon, Kyewon
Lee, Hancheol
Shin, Sanghoon
Cho, In-Jeong
Park, Sung-Ha
Lee, Sang-Hak
Jang, Yangsoo
Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
title Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
title_full Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
title_fullStr Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
title_full_unstemmed Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
title_short Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
title_sort differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599532/
https://www.ncbi.nlm.nih.gov/pubmed/23452437
http://dx.doi.org/10.1186/1475-2840-12-41
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