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Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping

BACKGROUND: (11)C-PiB has been developed as a positron-emission tomography (PET) ligand for evaluating fibrillar β-amyloid (Aβ) in the human brain. The ligand is rapidly metabolized, with approximately 10% of intact tracer remaining 30 min after injection. When (11)C-PiB is used as a treatment endpo...

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Detalles Bibliográficos
Autores principales:	Van Vlaslaer, Anne, Mortishire-Smith, Russell J, Mackie, Claire, Langlois, Xavier, Schmidt, Mark E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2013
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599558/ https://www.ncbi.nlm.nih.gov/pubmed/23406885 http://dx.doi.org/10.1186/2191-219X-3-10

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