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A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years

BACKGROUND: Pre-vaccination information on HPV type-specific prevalence in target populations is essential for designing and monitoring immunization strategies for cervical cancer (CC) prevention. Data on HPV prevalence in Italy are available for women over the age of 24 years, target of the populat...

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Autores principales: Giambi, Cristina, Donati, Serena, Carozzi, Francesca, Salmaso, Stefania, Declich, Silvia, Atti, Marta L Ciofi degli, Ronco, Guglielmo, Alibrandi, Maria P, Brezzi, Silvia, Collina, Natalina, Franchi, Daniela, Lattanzi, Amedeo, Minna, Maria C, Nannini, Roberto, Barretta, Elena, Burroni, Elena, Gillio-Tos, Anna, Macallini, Vincenzo, Pierotti, Paola, Bella, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599585/
https://www.ncbi.nlm.nih.gov/pubmed/23390953
http://dx.doi.org/10.1186/1471-2334-13-74
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author Giambi, Cristina
Donati, Serena
Carozzi, Francesca
Salmaso, Stefania
Declich, Silvia
Atti, Marta L Ciofi degli
Ronco, Guglielmo
Alibrandi, Maria P
Brezzi, Silvia
Collina, Natalina
Franchi, Daniela
Lattanzi, Amedeo
Minna, Maria C
Nannini, Roberto
Barretta, Elena
Burroni, Elena
Gillio-Tos, Anna
Macallini, Vincenzo
Pierotti, Paola
Bella, Antonino
author_facet Giambi, Cristina
Donati, Serena
Carozzi, Francesca
Salmaso, Stefania
Declich, Silvia
Atti, Marta L Ciofi degli
Ronco, Guglielmo
Alibrandi, Maria P
Brezzi, Silvia
Collina, Natalina
Franchi, Daniela
Lattanzi, Amedeo
Minna, Maria C
Nannini, Roberto
Barretta, Elena
Burroni, Elena
Gillio-Tos, Anna
Macallini, Vincenzo
Pierotti, Paola
Bella, Antonino
author_sort Giambi, Cristina
collection PubMed
description BACKGROUND: Pre-vaccination information on HPV type-specific prevalence in target populations is essential for designing and monitoring immunization strategies for cervical cancer (CC) prevention. Data on HPV prevalence in Italy are available for women over the age of 24 years, target of the population-based CC screening programmes; while data of HPV prevalence in younger ages are very limited. The present study enrolled Italian women aged 18–26 years in order to assess the prevalence and distribution of high-risk (HR) HPV types. Risk-factors correlated with HR-HPV positivity were also described. METHODS: A sample of 2,289 women was randomly selected from the resident population lists of ten Local Health Units (LHUs) located in six Italian Regions scattered across the country; both rural and urban LHUs were involved. Women aged between 18 and 26 years and living in the selected LHUs were included in the study; pregnant women and women who did not speak Italian were excluded. A total of 1,102 women met the inclusion criteria and agreed to participate. Participants were offered pap test and Hybrid-Capture 2 (HC2) test for HR-HPV types and genotyping was performed on positive smears. RESULTS: Out of 1,094 valid samples, 205 (18.7%) were HR-HPV positive. Women with 2–4 (OR(adj) = 4.15, 95%CI: 2.56-6.72) and ≥5 lifetime partners (OR(adj) = 10.63, 95%CI: 6.16-18.36) and women who have used any contraceptive in the last six months (OR(adj) = 1.67, 95%CI: 1.09-2.54) had a higher risk to be infected; women living with their partner had a lower risk (OR(adj) = 0.56, 95%CI: 0.34-0.92) to acquire infection than women living with parents/friends/alone. Among HC2 positive women, HPV16 was the most prevalent type (30.9%), followed by 31 (19.6%), 66 (12.9%), 51 (11.3%), 18 (8.8%), 56 (8.8%). Co-infections of HR-HC2 targeted types were found in 20.4% of positive samples. The HR-HPV prevalence in women with abnormal cytology (52.4%) was significantly higher than in women with normal cytology (14.6%); however 33.0% of HR-HPV infected women had an abnormal cytology. CONCLUSION: HR-HPV prevalence in Italian women aged 18–26 years was 19%, higher than what detected for older women, by other studies using the same molecular method and laboratory network; this result supports the choice of electing girls before the sexual debut as the primary target of HPV vaccination. The HPV type distribution found in this study may represent a baseline picture; an accurate post-vaccine surveillance is necessary to early detect a possible genotype replacement. The high prevalence of viral types other than vaccine-HPV types supports the necessity to guarantee the progression of CC screening programmes in vaccinated women.
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spelling pubmed-35995852013-03-17 A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years Giambi, Cristina Donati, Serena Carozzi, Francesca Salmaso, Stefania Declich, Silvia Atti, Marta L Ciofi degli Ronco, Guglielmo Alibrandi, Maria P Brezzi, Silvia Collina, Natalina Franchi, Daniela Lattanzi, Amedeo Minna, Maria C Nannini, Roberto Barretta, Elena Burroni, Elena Gillio-Tos, Anna Macallini, Vincenzo Pierotti, Paola Bella, Antonino BMC Infect Dis Research Article BACKGROUND: Pre-vaccination information on HPV type-specific prevalence in target populations is essential for designing and monitoring immunization strategies for cervical cancer (CC) prevention. Data on HPV prevalence in Italy are available for women over the age of 24 years, target of the population-based CC screening programmes; while data of HPV prevalence in younger ages are very limited. The present study enrolled Italian women aged 18–26 years in order to assess the prevalence and distribution of high-risk (HR) HPV types. Risk-factors correlated with HR-HPV positivity were also described. METHODS: A sample of 2,289 women was randomly selected from the resident population lists of ten Local Health Units (LHUs) located in six Italian Regions scattered across the country; both rural and urban LHUs were involved. Women aged between 18 and 26 years and living in the selected LHUs were included in the study; pregnant women and women who did not speak Italian were excluded. A total of 1,102 women met the inclusion criteria and agreed to participate. Participants were offered pap test and Hybrid-Capture 2 (HC2) test for HR-HPV types and genotyping was performed on positive smears. RESULTS: Out of 1,094 valid samples, 205 (18.7%) were HR-HPV positive. Women with 2–4 (OR(adj) = 4.15, 95%CI: 2.56-6.72) and ≥5 lifetime partners (OR(adj) = 10.63, 95%CI: 6.16-18.36) and women who have used any contraceptive in the last six months (OR(adj) = 1.67, 95%CI: 1.09-2.54) had a higher risk to be infected; women living with their partner had a lower risk (OR(adj) = 0.56, 95%CI: 0.34-0.92) to acquire infection than women living with parents/friends/alone. Among HC2 positive women, HPV16 was the most prevalent type (30.9%), followed by 31 (19.6%), 66 (12.9%), 51 (11.3%), 18 (8.8%), 56 (8.8%). Co-infections of HR-HC2 targeted types were found in 20.4% of positive samples. The HR-HPV prevalence in women with abnormal cytology (52.4%) was significantly higher than in women with normal cytology (14.6%); however 33.0% of HR-HPV infected women had an abnormal cytology. CONCLUSION: HR-HPV prevalence in Italian women aged 18–26 years was 19%, higher than what detected for older women, by other studies using the same molecular method and laboratory network; this result supports the choice of electing girls before the sexual debut as the primary target of HPV vaccination. The HPV type distribution found in this study may represent a baseline picture; an accurate post-vaccine surveillance is necessary to early detect a possible genotype replacement. The high prevalence of viral types other than vaccine-HPV types supports the necessity to guarantee the progression of CC screening programmes in vaccinated women. BioMed Central 2013-02-07 /pmc/articles/PMC3599585/ /pubmed/23390953 http://dx.doi.org/10.1186/1471-2334-13-74 Text en Copyright ©2013 Giambi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Giambi, Cristina
Donati, Serena
Carozzi, Francesca
Salmaso, Stefania
Declich, Silvia
Atti, Marta L Ciofi degli
Ronco, Guglielmo
Alibrandi, Maria P
Brezzi, Silvia
Collina, Natalina
Franchi, Daniela
Lattanzi, Amedeo
Minna, Maria C
Nannini, Roberto
Barretta, Elena
Burroni, Elena
Gillio-Tos, Anna
Macallini, Vincenzo
Pierotti, Paola
Bella, Antonino
A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years
title A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years
title_full A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years
title_fullStr A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years
title_full_unstemmed A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years
title_short A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years
title_sort cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in italian women aged 18–26 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599585/
https://www.ncbi.nlm.nih.gov/pubmed/23390953
http://dx.doi.org/10.1186/1471-2334-13-74
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