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Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells

BACKGROUND: Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-4 is encoded in its centrally located SAC (Selective for Apoptosis induction in...

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Detalles Bibliográficos
Autores principales:	Thayyullathil, Faisal, Pallichankandy, Siraj, Rahman, Anees, Kizhakkayil, Jaleel, Chathoth, Shahanas, Patel, Mahendra, Galadari, Sehamuddin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599610/ https://www.ncbi.nlm.nih.gov/pubmed/23442976 http://dx.doi.org/10.1186/1750-2187-8-2

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