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Ultra-deep mutant spectrum profiling: improving sequencing accuracy using overlapping read pairs
BACKGOUND: High throughput sequencing is beginning to make a transformative impact in the area of viral evolution. Deep sequencing has the potential to reveal the mutant spectrum within a viral sample at high resolution, thus enabling the close examination of viral mutational dynamics both within- a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599684/ https://www.ncbi.nlm.nih.gov/pubmed/23402258 http://dx.doi.org/10.1186/1471-2164-14-96 |