Cargando…

Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?

Calcitonin (Ct) is a tumour marker essential for the diagnosis and follow-up of medullary thyroid cancer (MTC). Accurate and consistent measurements of serum Ct are of critical importance. Ct measurements by different methods can differ, leading to difficulties in the interpretation of results. Seco...

Descripción completa

Detalles Bibliográficos
Autores principales: Daumerie, Chantal, Maiter, Dominique, Gruson, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599711/
https://www.ncbi.nlm.nih.gov/pubmed/23514568
http://dx.doi.org/10.1186/1756-6614-6-S1-S4
_version_ 1782263034755940352
author Daumerie, Chantal
Maiter, Dominique
Gruson, Damien
author_facet Daumerie, Chantal
Maiter, Dominique
Gruson, Damien
author_sort Daumerie, Chantal
collection PubMed
description Calcitonin (Ct) is a tumour marker essential for the diagnosis and follow-up of medullary thyroid cancer (MTC). Accurate and consistent measurements of serum Ct are of critical importance. Ct measurements by different methods can differ, leading to difficulties in the interpretation of results. Second generation assays for Ct have been developed and are now available in clinical laboratories. However, the lack of standardization for Ct assays remains a common problem with Ct assays. The reference interval and reliability should be carefully defined. The role of stimulated Ct for the diagnosis and follow-up of MTC should also be pointed out as the pentagastrin test is no more available in all countries. However, the stimulated test remains very useful to exclude MTC if the basal Ct serum level is in the grey zone (15-20 ng/L), after surgery to confirm the complete cure. A residual response after surgery could indicate a need for aggressive surgery or - in case of metastatic disease - could suggest the prognosis. High-dose Ca test (2.5mg/kg) seems to be a reliable and effective test for the diagnosis and follow-up of MTC. It seems more potent than pentagastrin with fewer side effects. The threshold able to discriminate healthy subjects from C-cell hyperplasia (CCH) cases for the stimulated Ct concentration is 184 ng/L for women and 1620 ng/L for men. As stimulated Ca test will eventually replace the pentagastrin test, there is a need to confirm or to modify the threshold identified for each assay individually.
format Online
Article
Text
id pubmed-3599711
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-35997112013-03-25 Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels? Daumerie, Chantal Maiter, Dominique Gruson, Damien Thyroid Res Review Calcitonin (Ct) is a tumour marker essential for the diagnosis and follow-up of medullary thyroid cancer (MTC). Accurate and consistent measurements of serum Ct are of critical importance. Ct measurements by different methods can differ, leading to difficulties in the interpretation of results. Second generation assays for Ct have been developed and are now available in clinical laboratories. However, the lack of standardization for Ct assays remains a common problem with Ct assays. The reference interval and reliability should be carefully defined. The role of stimulated Ct for the diagnosis and follow-up of MTC should also be pointed out as the pentagastrin test is no more available in all countries. However, the stimulated test remains very useful to exclude MTC if the basal Ct serum level is in the grey zone (15-20 ng/L), after surgery to confirm the complete cure. A residual response after surgery could indicate a need for aggressive surgery or - in case of metastatic disease - could suggest the prognosis. High-dose Ca test (2.5mg/kg) seems to be a reliable and effective test for the diagnosis and follow-up of MTC. It seems more potent than pentagastrin with fewer side effects. The threshold able to discriminate healthy subjects from C-cell hyperplasia (CCH) cases for the stimulated Ct concentration is 184 ng/L for women and 1620 ng/L for men. As stimulated Ca test will eventually replace the pentagastrin test, there is a need to confirm or to modify the threshold identified for each assay individually. BioMed Central 2013-03-14 /pmc/articles/PMC3599711/ /pubmed/23514568 http://dx.doi.org/10.1186/1756-6614-6-S1-S4 Text en Copyright ©2013 Daumerie et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Daumerie, Chantal
Maiter, Dominique
Gruson, Damien
Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
title Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
title_full Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
title_fullStr Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
title_full_unstemmed Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
title_short Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
title_sort serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599711/
https://www.ncbi.nlm.nih.gov/pubmed/23514568
http://dx.doi.org/10.1186/1756-6614-6-S1-S4
work_keys_str_mv AT daumeriechantal serumcalcitoninestimationinmedullarythyroidcancerbasalorstimulatedlevels
AT maiterdominique serumcalcitoninestimationinmedullarythyroidcancerbasalorstimulatedlevels
AT grusondamien serumcalcitoninestimationinmedullarythyroidcancerbasalorstimulatedlevels