Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply

BACKGROUND: Interferon-α (IFN-α) is an essential mediator of the antiviral response, which potently inhibits both early and late phases of HIV replication. The SAMHD1 deoxynucleoside triphosphate (dNTP) hydrolase represents the prototype of a new antiviral strategy we referred to as “nucleotide depl...

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Detalles Bibliográficos
Autores principales: Dragin, Loic, Nguyen, Laura Anh, Lahouassa, Hichem, Sourisce, Adèle, Kim, Baek, Ramirez, Bertha Cecilia, Margottin-Goguet, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599726/
https://www.ncbi.nlm.nih.gov/pubmed/23497353
http://dx.doi.org/10.1186/1742-4690-10-30

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