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Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients

BACKGROUND: This retrospective study was designed to investigate the clinical characteristics, diagnosis, treatment and prognosis of primary tracheobronchial mucoepidermoid carcinoma (MEC). METHODS: Clinical data were retrospectively analyzed from 32 patients with pathologically confirmed primary tr...

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Autores principales: Song, Zhengbo, Liu, Zhuo, Wang, Jiwen, Zhu, Huineng, Zhang, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599790/
https://www.ncbi.nlm.nih.gov/pubmed/23497031
http://dx.doi.org/10.1186/1477-7819-11-62
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author Song, Zhengbo
Liu, Zhuo
Wang, Jiwen
Zhu, Huineng
Zhang, Yiping
author_facet Song, Zhengbo
Liu, Zhuo
Wang, Jiwen
Zhu, Huineng
Zhang, Yiping
author_sort Song, Zhengbo
collection PubMed
description BACKGROUND: This retrospective study was designed to investigate the clinical characteristics, diagnosis, treatment and prognosis of primary tracheobronchial mucoepidermoid carcinoma (MEC). METHODS: Clinical data were retrospectively analyzed from 32 patients with pathologically confirmed primary tracheobronchial MEC between January 1990 and December 2010 at Zhejiang Cancer Hospital. The Kaplan-Meier methods were used to estimate and compare survival rates. RESULTS: There were 19 males and 13 females ranging in age from 7 to 73 years, with a median age of 28 years. Twenty-six of the 32 patients were treated with surgery alone. The other six patients were treated with surgery plus postoperative radiotherapy or chemotherapy. Six patients died during the follow-up time. The overall five-year survival rates were 81.25%, whereas the five-year survival rate of seven patients with high-grade tumors was only 28.6%. Stage I and II patients experienced better survival than Stage III and IV patients (the five-year survival rate was 100% and 43.6% respectively, P<0.001). CONCLUSIONS: Primary tracheobronchial MEC is a rare disease. Histologic grading and TNM (tumor-node-metastasis)staging are independent prognostic factors. Surgical resection is the primary treatment.
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spelling pubmed-35997902013-03-17 Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients Song, Zhengbo Liu, Zhuo Wang, Jiwen Zhu, Huineng Zhang, Yiping World J Surg Oncol Research BACKGROUND: This retrospective study was designed to investigate the clinical characteristics, diagnosis, treatment and prognosis of primary tracheobronchial mucoepidermoid carcinoma (MEC). METHODS: Clinical data were retrospectively analyzed from 32 patients with pathologically confirmed primary tracheobronchial MEC between January 1990 and December 2010 at Zhejiang Cancer Hospital. The Kaplan-Meier methods were used to estimate and compare survival rates. RESULTS: There were 19 males and 13 females ranging in age from 7 to 73 years, with a median age of 28 years. Twenty-six of the 32 patients were treated with surgery alone. The other six patients were treated with surgery plus postoperative radiotherapy or chemotherapy. Six patients died during the follow-up time. The overall five-year survival rates were 81.25%, whereas the five-year survival rate of seven patients with high-grade tumors was only 28.6%. Stage I and II patients experienced better survival than Stage III and IV patients (the five-year survival rate was 100% and 43.6% respectively, P<0.001). CONCLUSIONS: Primary tracheobronchial MEC is a rare disease. Histologic grading and TNM (tumor-node-metastasis)staging are independent prognostic factors. Surgical resection is the primary treatment. BioMed Central 2013-03-09 /pmc/articles/PMC3599790/ /pubmed/23497031 http://dx.doi.org/10.1186/1477-7819-11-62 Text en Copyright ©2013 Song et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Song, Zhengbo
Liu, Zhuo
Wang, Jiwen
Zhu, Huineng
Zhang, Yiping
Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients
title Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients
title_full Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients
title_fullStr Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients
title_full_unstemmed Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients
title_short Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients
title_sort primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599790/
https://www.ncbi.nlm.nih.gov/pubmed/23497031
http://dx.doi.org/10.1186/1477-7819-11-62
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