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Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients
BACKGROUND: Glycodelin is a cell surface glycoprotein offering a unique gender specific carbohydrate configuration. Sialylated carbohydrate structures, which are unusual for mammals, characterize Glycodelin isolated from amniotic fluid (Glycodelin A, GdA). Glycodelin in general exerts multiple, part...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599868/ https://www.ncbi.nlm.nih.gov/pubmed/23036050 http://dx.doi.org/10.1186/1756-0500-5-551 |
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author | Scholz, Christoph Heublein, Sabine Lenhard, Miriam Friese, Klaus Mayr, Doris Jeschke, Udo |
author_facet | Scholz, Christoph Heublein, Sabine Lenhard, Miriam Friese, Klaus Mayr, Doris Jeschke, Udo |
author_sort | Scholz, Christoph |
collection | PubMed |
description | BACKGROUND: Glycodelin is a cell surface glycoprotein offering a unique gender specific carbohydrate configuration. Sialylated carbohydrate structures, which are unusual for mammals, characterize Glycodelin isolated from amniotic fluid (Glycodelin A, GdA). Glycodelin in general exerts multiple, partly opposing functions ranging from immunosuppression to cell differentiation. As these markedly influence tumorigenesis, this study aimed to clarify whether expression of different Glycodelin isoforms is related to clinicopathological characteristics and prognosis of ovarian cancer patients. Further the use of Glycodelin as a serum marker in benign and malignant ovarian diseases was evaluated. METHODS: Ovarian cancer specimens (n = 152) were stained for Glycodelin with carbohydrate and peptide specific antibodies. Associations between Glycodelin expression and histological grading, FIGO stage as well as patient’s prognosis were examined. Glycodelin was correlated to expression of gonadotropin receptors and mucin-1, which are discussed as ovarian cancer tissue markers. In addition, Glycodelin serum concentrations were analyzed in patients suffering from benign (n = 73) or malignant (n = 38) ovarian neoplasias. RESULTS: Glycodelin A was found to be an independent prognostic marker for poor prognosis in advanced ovarian cancer patients. GdA staining correlated with gonadotropin receptor (FSHR and LHCGR) and with hCG expression. Gd expression showed a positive correlation with a tumour-associated epitope of mucin 1 (TA-MUC1). Further, compared to ovarian cancer, serum Gd was increased in patients with benign ovarian tumors. CONCLUSION: Glycodelin A might be related to tumor aggressiveness and poor clinical outcome in advanced epithelial ovarian cancer. Glycodelin serum levels found in patients suffering from benign ovarian tumors, might contribute to a more global attenuation during progression of these precursor lesions. |
format | Online Article Text |
id | pubmed-3599868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35998682013-03-17 Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients Scholz, Christoph Heublein, Sabine Lenhard, Miriam Friese, Klaus Mayr, Doris Jeschke, Udo BMC Res Notes Research Article BACKGROUND: Glycodelin is a cell surface glycoprotein offering a unique gender specific carbohydrate configuration. Sialylated carbohydrate structures, which are unusual for mammals, characterize Glycodelin isolated from amniotic fluid (Glycodelin A, GdA). Glycodelin in general exerts multiple, partly opposing functions ranging from immunosuppression to cell differentiation. As these markedly influence tumorigenesis, this study aimed to clarify whether expression of different Glycodelin isoforms is related to clinicopathological characteristics and prognosis of ovarian cancer patients. Further the use of Glycodelin as a serum marker in benign and malignant ovarian diseases was evaluated. METHODS: Ovarian cancer specimens (n = 152) were stained for Glycodelin with carbohydrate and peptide specific antibodies. Associations between Glycodelin expression and histological grading, FIGO stage as well as patient’s prognosis were examined. Glycodelin was correlated to expression of gonadotropin receptors and mucin-1, which are discussed as ovarian cancer tissue markers. In addition, Glycodelin serum concentrations were analyzed in patients suffering from benign (n = 73) or malignant (n = 38) ovarian neoplasias. RESULTS: Glycodelin A was found to be an independent prognostic marker for poor prognosis in advanced ovarian cancer patients. GdA staining correlated with gonadotropin receptor (FSHR and LHCGR) and with hCG expression. Gd expression showed a positive correlation with a tumour-associated epitope of mucin 1 (TA-MUC1). Further, compared to ovarian cancer, serum Gd was increased in patients with benign ovarian tumors. CONCLUSION: Glycodelin A might be related to tumor aggressiveness and poor clinical outcome in advanced epithelial ovarian cancer. Glycodelin serum levels found in patients suffering from benign ovarian tumors, might contribute to a more global attenuation during progression of these precursor lesions. BioMed Central 2012-10-05 /pmc/articles/PMC3599868/ /pubmed/23036050 http://dx.doi.org/10.1186/1756-0500-5-551 Text en Copyright ©2012 Scholz et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Scholz, Christoph Heublein, Sabine Lenhard, Miriam Friese, Klaus Mayr, Doris Jeschke, Udo Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients |
title | Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients |
title_full | Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients |
title_fullStr | Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients |
title_full_unstemmed | Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients |
title_short | Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients |
title_sort | glycodelin a is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599868/ https://www.ncbi.nlm.nih.gov/pubmed/23036050 http://dx.doi.org/10.1186/1756-0500-5-551 |
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