Cargando…

Experience and challenges from clinical trials with malaria vaccines in Africa

Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades. Despite this, there is currently no licensed malari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mwangoka, Grace, Ogutu, Bernhards, Msambichaka, Beverly, Mzee, Tutu, Salim, Nahya, Kafuruki, Shubis, Mpina, Maxmillian, Shekalaghe, Seif, Tanner, Marcel, Abdulla, Salim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Case Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599886/ https://www.ncbi.nlm.nih.gov/pubmed/23496910 http://dx.doi.org/10.1186/1475-2875-12-86

Ejemplares similares

Challenges of establishing a Community Advisory Board (CAB) in a low-income, low-resource setting: experiences from Bagamoyo, Tanzania
por: Shubis, Kafuruki, et al.
Publicado: (2009)

The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01(E) on protective efficacy and anti-circumsporozoite protein antibody avidity in African infants
por: Ajua, Anthony, et al.
Publicado: (2015)

Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests
por: Guirou, Etienne A., et al.
Publicado: (2020)

Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent period
por: Rothen, Julian, et al.
Publicado: (2018)

Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania
por: Schindler, Tobias, et al.
Publicado: (2019)

Stakeholders’ opinions and questions regarding the anticipated malaria vaccine in Tanzania
por: Mtenga, Sally, et al.
Publicado: (2016)

Malaria management - progress made and challenges still to face
por: Ogutu, Bernhards R
Publicado: (2009)

Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02(D) malaria vaccine in infants living in a malaria-endemic region
por: Abdulla, Salim, et al.
Publicado: (2013)

Clinical performance of an automated reader in interpreting malaria rapid diagnostic tests in Tanzania
por: Shekalaghe, Seif, et al.
Publicado: (2013)

Virosome-Formulated Plasmodium falciparum AMA-1 & CSP Derived Peptides as Malaria Vaccine: Randomized Phase 1b Trial in Semi-Immune Adults & Children
por: Cech, Patrick Georges, et al.
Publicado: (2011)

Neonatal Deaths in Rural Southern Tanzania: Care-Seeking and Causes of Death
por: Mrisho, Mwifadhi, et al.
Publicado: (2012)

Controlled human malaria infections using aseptic, purified cryopreserved Plasmodium falciparum sporozoites administered by needle and syringe
por: Billingsley, Peter, et al.
Publicado: (2014)

Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers
por: Duffy, Fergal J., et al.
Publicado: (2021)

Insufficient Fruit and Vegetable Intake in a Low- and Middle-Income Setting: A Population-Based Survey in Semi-Urban Tanzania
por: Msambichaka, Beverly, et al.
Publicado: (2018)

A Cross-Sectional Examination of Physical Activity Levels and Their Socio-Demographic Determinants in Southern Tanzania
por: Msambichaka, Beverly, et al.
Publicado: (2018)

Controlled Human Malaria Infection of Tanzanians by Intradermal Injection of Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites
por: Shekalaghe, Seif, et al.
Publicado: (2014)

Field evaluation of the novel One Step Malaria Pf and Pf/Pv rapid diagnostic tests and the proportion of HRP-2 gene deletion identified on samples collected in the Pwani region, Tanzania
por: Mwangonela, Zena E., et al.
Publicado: (2023)

RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials
por: van den Berg, Machteld, et al.
Publicado: (2019)

The epidemiology of chronic kidney disease and the association with non-communicable and communicable disorders in a population of sub-Saharan Africa
por: Hodel, Nikolai C., et al.
Publicado: (2018)

Assessment of parental perception of malaria vaccine in Tanzania
por: Romore, Idda, et al.
Publicado: (2015)

Sustainable development of a GCP-compliant clinical trials platform in Africa: the Malaria Clinical Trials Alliance perspective
por: Ogutu, Bernhards R, et al.
Publicado: (2010)

Assessment of diabetes and prediabetes prevalence and predictors by HbA1c in a population from sub-Saharan Africa with a high proportion of anemia: a prospective cross-sectional study
por: Hodel, Nikolai Carl, et al.
Publicado: (2020)

Care-Seeking Dynamics among Patients with Diabetes Mellitus and Hypertension in Selected Rural Settings in Kenya
por: Karinja, Miriam, et al.
Publicado: (2019)

Quinine plus clindamycin vs artemether-lumefantrine for treatment of uncomplicated falciparum malaria in western Kenya
por: Obonyo, Charles O., et al.
Publicado: (2022)

Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether–lumefantrine
por: Shekalaghe, Seif, et al.
Publicado: (2020)

The Equatoguinean Malaria Vaccine Initiative: From the Launching of a Clinical Research Platform to Malaria Elimination Planning in Central West Africa
por: Billingsley, Peter F., et al.
Publicado: (2020)

Enterobiasis and strongyloidiasis and associated co-infections and morbidity markers in infants, preschool- and school-aged children from rural coastal Tanzania: a cross-sectional study
por: Salim, Nahya, et al.
Publicado: (2014)

Malaria hospitalisation in East Africa: age, phenotype and transmission intensity
por: Kamau, Alice, et al.
Publicado: (2022)

Prevalence and assessment of malnutrition among children attending the Reproductive and Child Health clinic at Bagamoyo District Hospital, Tanzania
por: Juma, Omar Ali, et al.
Publicado: (2016)

Response to “Poor control vaccines in two randomised trials of malaria vaccine?”
por: Bejon, Philip, et al.
Publicado: (2009)

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data
por: Bejon, Philip, et al.
Publicado: (2013)

The content of African diets is adequate to achieve optimal efficacy with fixed-dose artemether-lumefantrine: a review of the evidence
por: Premji, Zulfiqarali G, et al.
Publicado: (2008)

Referral challenges and outcomes of neonates received at Muhimbili National Hospital, Dar es Salaam, Tanzania
por: Kiputa, Mpokigwa, et al.
Publicado: (2022)

Comparison of bioavailability between the most available generic tablet formulation containing artemether and lumefantrine on the Tanzanian market and the innovator’s product
por: Minzi, Omary MS, et al.
Publicado: (2013)

Policy analysis for deciding on a malaria vaccine RTS,S in Tanzania
por: Romore, Idda, et al.
Publicado: (2016)

Nurses’ knowledge, perceived challenges, and recommended solutions regarding premature infant care: A mixed method study in the referral and tertiary hospitals in Dar es salaam, Tanzania
por: Mwikali, Mwajuma, et al.
Publicado: (2023)

Development of a pediatric formulation for treatment of P. falciparum malaria: Coartem(®) (artemether-lumefantrine) Dispersible
por: Bassat, Quique, et al.
Publicado: (2014)

Distribution and Risk Factors for Plasmodium and Helminth Co-infections: A Cross-Sectional Survey among Children in Bagamoyo District, Coastal Region of Tanzania
por: Salim, Nahya, et al.
Publicado: (2015)

Prevalence of malaria parasites in adults and its determinants in malaria endemic area of Kisumu County, Kenya
por: Jenkins, Rachel, et al.
Publicado: (2015)

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care
por: Vekemans, Johan, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2mnqd2tump6kgp5ko3rir0mvc4