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Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990

BACKGROUND AND PURPOSE: Heat shock Protein 90 (Hsp90) is a molecular chaperone that folds, stabilizes, and functionally regulates many cellular proteins involved in oncogenic signaling and in the regulation of radiosensitivity. It is upregulated in response to stress such a heat. Hyperthermia is a p...

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Detalles Bibliográficos
Autores principales:	Milanović, Dušan, Firat, Elke, Grosu, Anca Ligia, Niedermann, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599905/ https://www.ncbi.nlm.nih.gov/pubmed/23448094 http://dx.doi.org/10.1186/1748-717X-8-42

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